Perez-Gomez Maria V, Sanchez-Niño Maria D, Ortiz Alberto
IIS-Fundacion Jimenez Diaz, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain.
Fundacion Renal Iñigo Alvarez de Toledo-IRSIN and REDINREN, Madrid, Spain.
Clin Kidney J. 2020 Mar 19;13(3):281-286. doi: 10.1093/ckj/sfz171. eCollection 2020 Jun.
In this issue of , Gamayo describe two cases of anti-low-density lipoprotein receptor-related protein 2 (LRP2) nephropathy. This is a recently described entity that has features of both tubulointerstitial disease and segmental membranous nephropathy. The originality of the present report consists of the association of a disease thought to be rare (only 13 in prior described patients, 11 in the past year) with B-cell lymphoproliferative disease. Together with the finding of a third case among 224 elderly patients studied, this raises the issue of the underdiagnoses of LRP2 nephropathy, on top of the potential association to B-cell malignancy. We now put these findings in context within the wider frame of autoimmunity against megalin/LRP2 and related antigens such as Fx1A and CD69.
在本期杂志中，加马约描述了两例抗低密度脂蛋白受体相关蛋白2（LRP2）肾病病例。这是一种最近才被描述的疾病实体，具有肾小管间质疾病和节段性膜性肾病的特征。本报告的独特之处在于，一种被认为罕见的疾病（此前报道的患者中仅有13例，过去一年中有11例）与B细胞淋巴增殖性疾病相关联。在对224例老年患者的研究中发现了第三例病例，这不仅引发了LRP2肾病诊断不足的问题，还涉及到其与B细胞恶性肿瘤的潜在关联。我们现在将这些发现置于针对巨膜蛋白/LRP2以及相关抗原（如Fx1A和CD69）的自身免疫这一更广泛的背景中进行考量。
