Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong, Shantou, China.
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Acta Ophthalmol. 2021 Mar;99(2):e215-e221. doi: 10.1111/aos.14542. Epub 2020 Jul 23.
To investigate photoreceptor degeneration in retinitis pigmentosa (RP) by quantitatively analysing optical intensity of ellipsoid zone (EZ) on optical coherence tomography (OCT).
We conducted OCT line scans of the horizontal meridian in 24 eyes of 24 RP patients and 30 eyes of 30 healthy controls and obtained longitudinal reflectance profiles using ImageJ at every 5 pixels. Relative optical intensity was calculated from dividing the peak of EZ by the mean of the whole retina.
The optical intensity of EZ variation followed a similar pattern in all patients. It decreased with eccentricity and then vanished, regardless whether it was normal or reduced at the fovea. The mean relative optical intensity of EZ in RP patients was 0.69 ± 0.13 to that of control subjects at the location just before it disappeared. The relative optical intensity of EZ at fovea was significantly correlated with the best-corrected visual acuity in patients (r = -0.617, p = 0.001).
The optical intensity of EZ detected by OCT can serve as a biomarker for early detection of photoreceptor degeneration in RP.
通过定量分析光相干断层扫描（OCT）中的椭圆体带（EZ）的光强度，研究色素性视网膜炎（RP）中的光感受器变性。
我们对 24 名 RP 患者的 24 只眼和 30 名健康对照者的 30 只眼进行了水平子午线 OCT 线扫描，并使用 ImageJ 每隔 5 个像素获得纵向反射率曲线。相对光强度通过将 EZ 的峰值除以整个视网膜的平均值来计算。
所有患者的 EZ 光强度变化模式相似。它随离焦而减少，然后消失，无论在黄斑区是否正常或减少。RP 患者 EZ 的平均相对光强度在其消失前的位置为 0.69 ± 0.13，与对照组相比。黄斑区 EZ 的相对光强度与患者最佳矫正视力显著相关（r = -0.617，p = 0.001）。
OCT 检测到的 EZ 光强度可作为 RP 中光感受器变性早期检测的生物标志物。
