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恶性疟原虫和诺氏疟原虫这两种疟原虫在红细胞表面受体上存在差异的证据。

Evidence for differences in erythrocyte surface receptors for the malarial parasites, Plasmodium falciparum and Plasmodium knowlesi.

作者信息

Miller L H, Haynes J D, McAuliffe F M, Shiroishi T, Durocher J R, McGinniss M H

出版信息

J Exp Med. 1977 Jul 1;146(1):277-81. doi: 10.1084/jem.146.1.277.

Abstract

Human erythrocytes lacking various blood group determinants were susceptible to invasion by Plasmodium falciparum including Duffy-negative erythrocytes that are refractory to invasion by Plasmodium knowlesi. Erythrocytes treated with trypsin or neuraminidase had reduced susceptibility of P. falciparum and normal susceptibility to P. knowlesi. Chymotrypsin treatment (0.1 mg/ml) blocked invasion only by P. knowlesi. The differential effect of enzymatic cleavage of determinats from the erythrocyte surface on invasion by these parasites suggests that P. falciparum and P. knowlesi interact with different determinants on the erythrocyte surface.

摘要

缺乏各种血型决定簇的人类红细胞易受恶性疟原虫侵袭,包括对诺氏疟原虫侵袭具有抗性的达菲阴性红细胞。用胰蛋白酶或神经氨酸酶处理过的红细胞对恶性疟原虫的易感性降低,而对诺氏疟原虫的易感性正常。胰凝乳蛋白酶处理(0.1毫克/毫升)仅阻断诺氏疟原虫的侵袭。红细胞表面决定簇的酶切对这些寄生虫侵袭的不同影响表明,恶性疟原虫和诺氏疟原虫与红细胞表面的不同决定簇相互作用。

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Protein synthesis in vitro by cryopreserved Plasmodium falciparum.
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