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比较基因组学对一种常见的被错误鉴定的类似生物体的洞察。

Comparative genomic insights into - a commonly misidentified -like organism.

机构信息

UCD-Centre for Food Safety, School of Public Health, Physiotherapy & Sports Science, University College Dublin, Belfield, Dublin D04 N2E5, Ireland.

Institute for Food Safety and Hygiene, University of Zurich, Zurich, Switzerland.

出版信息

Microb Genom. 2020 Sep;6(9). doi: 10.1099/mgen.0.000411. Epub 2020 Jul 23.

DOI:10.1099/mgen.0.000411
PMID:32701425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7643974/
Abstract

Food-associated outbreaks linked to enteropathogenic are of concern to public health. Pigs and their meat are recognized risk factors for transmission of . This study aimed to describe the comparative genomics of along with a number of misclassified isolates, now constituting the recently described . The latter was originally cultured from an environmental sample taken at a pig slaughterhouse. Unique features were identified in the genome of including a novel integrative conjugative element (ICE), denoted as ICE contained within a 255 kbp region of plasticity. In addition, a zebrafish embryo infection model was adapted and applied to assess the virulence potential among isolates including .

摘要

与食源性病原体相关的疾病爆发引起了公众健康的关注。猪及其肉类被认为是传播肠致病性 的危险因素。本研究旨在描述 的比较基因组学，以及一些被错误分类的 分离株，这些分离株现在构成了最近描述的 。后者最初是从一个养猪场的环境样本中培养出来的。在 的基因组中发现了一些独特的特征，包括一个新的整合性和可转移性元件（ICE），称为 ICE，它包含在一个 255 kbp 的可塑性区域内。此外，还适应和应用了斑马鱼胚胎感染模型来评估包括 在内的 分离株的毒力潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a4/7643974/49b869ed003f/mgen-6-411-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a4/7643974/e575ecc704ad/mgen-6-411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a4/7643974/7e0c1deb33a8/mgen-6-411-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a4/7643974/9daea6e3820b/mgen-6-411-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a4/7643974/49b869ed003f/mgen-6-411-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a4/7643974/e575ecc704ad/mgen-6-411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a4/7643974/7e0c1deb33a8/mgen-6-411-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a4/7643974/9daea6e3820b/mgen-6-411-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a4/7643974/49b869ed003f/mgen-6-411-g004.jpg

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