NHS Blood and Transplant/Public Health England Epidemiology Unit, NHS Blood and Transplant, London, UK.
NHS Blood and Transplant/Public Health England Epidemiology Unit, Public Health England, London, UK.
Vox Sang. 2020 Nov;115(8):637-646. doi: 10.1111/vox.12976. Epub 2020 Jul 23.
Injecting drug use (IDU), a permanent deferral for blood donors, was included in a review of donor selection criteria completed in 2017. Here, we describe what is known about IDU in blood donors in the United Kingdom (UK).
Data were obtained from routine surveillance of donation testing and confirmed positive donors and a 2013/2014 UK survey of behaviour and compliance in screen-negative donors.
Between 2009 and 2018, of 22 UK million donations screened, IDU was self-reported at the post-test discussion in 5% (86/1777) of donors with confirmed positive donations. Recent injecting within 12 months was reported in 8 HCV-positive donors, but only in 1/14 donors where it was clear HCV infection had been acquired in the previous 12 months. Of 65 439 survey responders, 25 reported IDU, which when weighted to the donor population gave 99·95% compliance. Most of the 111 donors reporting IDU felt it was not important to their donation, mainly because their injecting was in the past, while three HCV-positive recent injectors reported not sharing needles so presumably felt safe to donate.
Compliance with the permanent deferral appeared extremely high with low levels of injecting reported by donors, mainly in the past. This agreed with the low-incident HCV infection observed in UK donors. These data contributed to a recommendation to reduce the deferral to 1 year. Ways of improving compliance in those few donors at current increased risk of infection need to be investigated.
静脉注射吸毒(IDU)是献血者的永久性暂缓献血原因,该原因已纳入 2017 年完成的献血者选择标准审查。在此,我们描述英国(UK)献血者中 IDU 的已知情况。
数据来自献血检测的常规监测以及确认阳性献血者,以及 2013/2014 年 UK 对阴性筛查献血者行为和合规性的调查。
在 2009 年至 2018 年间,在筛查的 2200 万 UK 次献血中,在确认阳性献血者的检测后讨论中,有 5%(86/1777)的献血者自述有 IDU。最近在 12 个月内注射的情况在 8 例 HCV 阳性献血者中报告,但仅在 14 例明确 HCV 感染是在过去 12 个月内获得的献血者中报告。在 65439 名调查应答者中,有 25 人报告有 IDU,将其加权到献血人群中,得到了 99.95%的合规率。报告 IDU 的 111 名献血者中,大多数人认为这对他们的献血不重要,主要是因为他们的注射是过去的事情,而 3 名 HCV 阳性的近期注射者报告没有共用针头,因此大概认为献血是安全的。
永久性暂缓献血的合规率非常高,献血者报告的注射量很低,主要是在过去。这与 UK 献血者中观察到的低 HCV 感染发生率一致。这些数据有助于推荐将暂缓时间缩短至 1 年。需要调查如何提高那些目前感染风险增加的少数献血者的合规性。