Bio-Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama, Japan.
Bio-Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama, Japan.
Nanomedicine. 2020 Oct;29:102270. doi: 10.1016/j.nano.2020.102270. Epub 2020 Jul 21.
Glioblastoma is the most destructive type of malignant brain tumor in humans due to cancer relapse. Latest studies have indicated that cancer cells are more reliant on autophagy for survival than non-cancer cells. Autophagy is entitled as programmed cell death type II and studies imply that it is a comeback of cancer cells to innumerable anti-cancer therapies. To diminish the adverse consequences of chemotherapeutics, numerous herbs of natural origin have been retained in cancer treatments. Additionally, autophagy induction occurs via their tumor suppressive actions that could cause cell senescence and increase apoptosis-independent cell death. However, most of the drugs have poor solubility and thus nano drug delivery systems possess excessive potential to improve the aqueous solubility and bioavailability of encapsulated drugs. There is a pronounced need for more therapies for glioblastoma treatment and hereby, the fundamental mechanisms of natural autophagy modulators in glioblastoma are prudently reviewed in this article.
胶质母细胞瘤是人类最具破坏性的恶性脑肿瘤，因为癌症会复发。最新研究表明，癌细胞比非癌细胞更依赖自噬来生存。自噬被称为程序性细胞死亡 II 型，研究表明，它是癌细胞对无数种抗癌疗法的反弹。为了减少化疗的不良后果，许多天然来源的草药被保留在癌症治疗中。此外，自噬的诱导是通过其肿瘤抑制作用发生的，这可能导致细胞衰老和增加凋亡不依赖的细胞死亡。然而，大多数药物的溶解度较差，因此纳米药物递送系统具有很大的潜力来提高包裹药物的水溶解度和生物利用度。因此，迫切需要更多的胶质母细胞瘤治疗方法，本文谨慎地综述了天然自噬调节剂在胶质母细胞瘤中的基本作用机制。
