Department of Breast and Thyroid Surgery, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, 312000, Zhejiang Province, China.
Department of Pharmacy, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, China.
Curr Top Med Chem. 2020;20(27):2442-2458. doi: 10.2174/1568026620666200722110808.
Nanotechnology has recently provided exciting platforms in the field of anticancer research with promising potentials for improving drug delivery efficacy and treatment outcomes. Nanoparticles (NPs) possess different advantages over the micro and bulk therapeutic agents, including their capability to carry high payloads of drugs, with prolonged half-life, reduced toxicity of the drugs, and increased targeting efficiency. The wide variety of nanovectors, coupled with different conjugation and encapsulation methods available for different theranostic agents provide promising opportunities to fine-tune the pharmacological properties of these agents for more effective cancer treatment methods. This review discusses applications of NPs-assisted chemotherapy in preclinical and clinical settings and recent advances in design and synthesis of different nanocarriers for chemotherapeutic agents. Moreover, physicochemical properties of different nanocarriers, their impacts on different tumor targeting strategies and effective parameters for efficient targeted drug delivery are discussed. Finally, the current approved NPs-assisted chemotherapeutic agents for clinical applications and under different phases of clinical trials are discussed.
纳米技术最近在抗癌研究领域提供了令人兴奋的平台，具有提高药物输送效果和治疗结果的潜力。与微和大治疗剂相比，纳米颗粒（NPs）具有不同的优势，包括能够携带高载药量的药物、延长药物半衰期、降低药物毒性以及提高靶向效率。广泛的纳米载体，加上不同的偶联和封装方法可用于不同的治疗剂，为精细调整这些药物的药理特性提供了有前途的机会，以实现更有效的癌症治疗方法。本文综述了 NPs 辅助化疗在临床前和临床环境中的应用，以及设计和合成不同纳米载体用于化疗药物的最新进展。此外，还讨论了不同纳米载体的物理化学性质、对不同肿瘤靶向策略的影响以及有效参数对于高效靶向药物输送的影响。最后，讨论了目前临床应用的和处于不同临床试验阶段的 NPs 辅助化疗药物。
