Cui Na, Yu Zhanbiao, Chen Zhi, Chen Ning
Na Cui, Department of ICU, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, P. R. China.
Zhanbiao Yu, Department of ICU, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, P. R. China.
Pak J Med Sci. 2020 Jul-Aug;36(5):1011-1014. doi: 10.12669/pjms.36.5.2143.
To explore the correlation of procalcitonin (PCT) and gelsolin (GSN) with the prognosis of urosepsis patients.
The data of 71 urosepsis patients from March 2015 to April 2019 who were admitted to and treated in Affiliated Hospital of Hebei University were analyzed and compared with those of 92 healthy persons. Serum PCT and plasma GSN levels at different times after treatment were detected. According to prognosis, patients were classified into the good prognosis group or the poor prognosis group. The serum PCT and plasma GSN levels of both groups were compared.
The serum PCT level of the urosepsis group on the 1, 3, 5 and 7 days was obviously higher than that of the control group (P<0.05). The plasma GSN levels of the urosepsis group on the 1, 3, 5 and 7 days were obviously lower than those of the control group (P<0.05). The serum PCT level of the poor prognosis group on the 1, 3, 5 and 7 days was obviously higher than that of the good prognosis group (P<0.05). The plasma GSN level of the poor prognosis group on the 1, 3, 5 and 7 days was obviously lower than that of the good prognosis group (P<0.05). PCT was an independent risk factor influencing the prognosis of urosepsis patients and that GSN was a protective factor (P<0.05).
The serum PCT and plasma GSN levels can accurately predict the severity and prognosis of urosepsis patients and reflect the disease state of early urosepsis patients. High PCT levels and low GSN levels indicate poor prognosis, and clinicians should consider these values.
探讨降钙素原（PCT）和凝溶胶蛋白（GSN）与尿脓毒症患者预后的相关性。
分析2015年3月至2019年4月在河北大学附属医院收治并治疗的71例尿脓毒症患者的数据，并与92例健康人的数据进行比较。检测治疗后不同时间的血清PCT和血浆GSN水平。根据预后情况，将患者分为预后良好组和预后不良组。比较两组的血清PCT和血浆GSN水平。
尿脓毒症组第1、3、5和7天的血清PCT水平明显高于对照组（P<0.05）。尿脓毒症组第1、3、5和7天的血浆GSN水平明显低于对照组（P<0.05）。预后不良组第1、3、5和7天的血清PCT水平明显高于预后良好组（P<0.05）。预后不良组第1、3、5和7天的血浆GSN水平明显低于预后良好组（P<0.05）。PCT是影响尿脓毒症患者预后的独立危险因素，而GSN是保护因素（P<0.05）。
血清PCT和血浆GSN水平可准确预测尿脓毒症患者的严重程度和预后，并反映早期尿脓毒症患者的疾病状态。PCT水平高和GSN水平低表明预后不良，临床医生应考虑这些值。
