Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yishan Road, Shanghai, 200233, China.
Biomed Res Int. 2019 Jul 22;2019:4693528. doi: 10.1155/2019/4693528. eCollection 2019.
Keloids are hard nodules or plaques formed by excessive proliferation of connective tissue. Radiotherapy, widely used in various benign and malignant skin diseases, is an effective treatment for keloids. This work evaluates Intrabeam photon radiotherapy in the management of keloids.
Fourteen patients who have undergone Intrabeam radiotherapy for a total of 15 sites of keloids were followed up. Twelve cases were first onset and the other two had recurrent diseases. Thirteen patients underwent surgical resection of keloids before radiotherapy. One relapsing patient received only 2 rounds of radiation therapy as she could not be reoperated. Radiotherapy was divided into 2 sessions on days 0 and 3 after surgery. The dose was 4 or 5 Gy each time for 3 min 14 s to 12 min 1 s. In addition, we compared our data to the recurrence of keloids in fourteen patients who had previously been exposed to electron beam using conventional accelerators.
We analyzed the treatment for adverse reactions and recurrence. In the Intrabeam group, one patient developed superficial skin ulcers a month after treatment. No one experienced wound rupture, bleeding, infection, skin contractures, or obvious hyperpigmentation. None of the fourteen cases showed any recurrence so far after on median 22.5 months of follow-up. Five patients in the electron beam group relapsed 3 to 10 months after treatment.
Here, Intrabeam photon radiotherapy was shown to be an effective treatment for keloid scars and it is therefore recommended for management of this disease.
瘢痕疙瘩是由结缔组织过度增生形成的硬结或斑块。放射治疗广泛应用于各种良性和恶性皮肤疾病，是治疗瘢痕疙瘩的有效方法。本研究评估了 Intrabeam 光子放疗在瘢痕疙瘩治疗中的应用。
对 14 名接受 Intrabeam 放疗治疗共 15 处瘢痕疙瘩的患者进行了随访。12 例为初发，2 例为复发。13 例患者在放疗前接受了瘢痕疙瘩切除术。1 例复发患者因无法再次手术仅接受了 2 轮放疗。放疗在术后第 0 天和第 3 天分为 2 个疗程，每次剂量为 4 或 5Gy，持续时间为 3 分 14 秒至 12 分 1 秒。此外，我们将我们的数据与之前使用常规加速器的电子束治疗的 14 名患者的瘢痕疙瘩复发情况进行了比较。
我们分析了不良反应和复发的治疗情况。在 Intrabeam 组中，1 例患者在治疗后 1 个月出现皮肤浅表溃疡。无 1 例患者出现伤口破裂、出血、感染、皮肤挛缩或明显色素沉着。在 14 例患者中，中位随访 22.5 个月后，目前均无任何复发。电子束组 5 例患者在治疗后 3 至 10 个月复发。
Intrabeam 光子放疗是治疗瘢痕疙瘩的有效方法，因此推荐用于该病的治疗。
