苯并噻唑类化合物作为潜在的抗病毒药物。
Benzothiazoles as potential antiviral agents.
机构信息
Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
出版信息
J Pharm Pharmacol. 2020 Nov;72(11):1459-1480. doi: 10.1111/jphp.13331. Epub 2020 Jul 24.
OBJECTIVES
The recent viral pandemic poses a unique challenge for healthcare providers. Despite the remarkable progress, the number of novel antiviral agents in the pipeline is woefully inadequate against the evolving virulence and drug resistance of current viruses. This highlights the urgent need for new and improved vaccines, diagnostics and therapeutic agents to obviate the viral pandemic.
KEY FINDINGS
Benzothiazole plays a pivotal role in the design and development of antiviral drugs. This is evident from the fact that it comprises many clinically useful agents. The current review is aimed to provide an insight into the recent development of benzothiazole-based antiviral agents, with a special focus on their structure-activity relationships and lead optimisation. One hundred and five articles were initially identified, and from these studies, 64 potential novel lead molecules and main findings were highlighted in this review.
SUMMARY
We hope this review will provide a logical perspective on the importance of improving the future designs of novel broad-spectrum benzothiazole-based antiviral agents to be used against emerging viral diseases.
目的
最近的病毒性大流行给医疗保健提供者带来了独特的挑战。尽管取得了显著的进展，但针对当前病毒不断变化的毒力和耐药性，在研的新型抗病毒药物数量严重不足。这凸显了迫切需要新的和改进的疫苗、诊断和治疗药物来消除病毒性大流行。
主要发现
苯并噻唑在抗病毒药物的设计和开发中起着关键作用。这从它包含许多临床有用的药物这一事实就可以看出。本综述旨在深入了解基于苯并噻唑的抗病毒药物的最新进展，特别关注其结构-活性关系和先导优化。最初确定了 105 篇文章，从这些研究中，本综述重点介绍了 64 种潜在的新型先导分子和主要发现。
总结
我们希望本综述将为改进新型广谱基于苯并噻唑的抗病毒药物的未来设计以用于应对新出现的病毒性疾病提供一个合理的视角。
Zotero 插件