Pharmacy Faculty, Para Federal University , Belem, Brazil.
Global Health Division, Menzies School of Health Research and Charles Darwin University , Darwin, Australia.
Pathog Glob Health. 2020 Oct;114(7):388-392. doi: 10.1080/20477724.2020.1799166. Epub 2020 Jul 24.
Primaquine is still the first-line drug to eliminate hypnozoites of . The therapeutic efficacy is related to the total dose administered. In several endemic areas, the drug is administered for children in an age-based regimen, which can lead to inadequate exposure, increasing the rates of recurrence of the infection. The present study aims to describe the mg/kg total dose of primaquine administered to children for treatment for vivax malaria when an age-based regimen is used and to measure the plasma concentrations of primaquine and carboxyprimaquine. A total of 85 children were included in the study. The total dose of primaquine administered based on mg/kg had a median value of 3.22 mg/kg. The percentage of patients with a total dose below the required dose of 3.5 mg/kg was 55.75%. The median primaquine maximum concentration was 94 ng/ml. For carboxy-primaquine, the median maximum concentration was 375 ng/ml. The results suggest that age-based dosing regimens likely lead to substantial under-dosing of primaquine, which is evident in the youngest children and is reflected in decreased levels of primaquine and carboxy-primaquine in plasma samples 13.
伯氨喹仍然是消除间日疟休眠子的一线药物。疗效与给予的总剂量有关。在几个流行地区，儿童按年龄组给药，这可能导致剂量不足，增加感染复发率。本研究旨在描述在使用年龄组方案治疗间日疟时，儿童接受的伯氨喹毫克/公斤总剂量，并测量伯氨喹和羧基伯氨喹的血浆浓度。共有 85 名儿童纳入研究。基于 mg/kg 的伯氨喹总剂量中位数为 3.22 mg/kg。总剂量低于 3.5 mg/kg 所需剂量的患者百分比为 55.75%。伯氨喹最大浓度中位数为 94ng/ml。对于羧基伯氨喹，最大浓度中位数为 375ng/ml。结果表明，基于年龄的剂量方案可能导致伯氨喹的大量剂量不足，这在最小的儿童中尤为明显，反映在血浆样本中伯氨喹和羧基伯氨喹的水平降低。
