Krause Bernardo J, Artigas Rocio, Sciolla Andres F, Hamilton James
Instituto de Ciencias de la Salud, Universidad de O''Higgins, Rancagua, Chile.
CUIDA - Centro de Investigación del Abuso y la Adversidad Temprana, Pontificia Universidad Católica de Chile, Avenida Libertador Bernardo O'Higgins 340, Santiago, Chile.
Epigenomics. 2020 Jul;12(14):1239-1255. doi: 10.2217/epi-2020-0042. Epub 2020 Jul 24.
Adverse childhood experiences (ACE) impair health and life expectancy and may result in an epigenetic signature that drives increased morbidity primed during early stages of life. This literature review focuses on the current evidence for epigenetic-mediated programming of brain and immune function resulting from ACE. To address this aim, a total of 88 articles indexed in PubMed before August 2019 concerning ACE and epigenetics were surveyed. Current evidence partially supports epigenetic programming of the hypothalamic-pituitary-adrenal axis, but convincingly shows that ACE impairs immune function. Additionally, the needs and challenges that face this area are discussed in order to provide a framework that may help to clarify the role of epigenetics in the long-lasting effects of ACE.
童年不良经历（ACE）会损害健康和预期寿命，并可能导致一种表观遗传特征，这种特征会促使在生命早期引发的发病率增加。这篇文献综述聚焦于童年不良经历导致的大脑和免疫功能表观遗传介导编程的现有证据。为实现这一目标，我们调查了2019年8月之前在PubMed上索引的88篇关于童年不良经历和表观遗传学的文章。现有证据部分支持下丘脑-垂体-肾上腺轴的表观遗传编程，但令人信服地表明童年不良经历会损害免疫功能。此外，还讨论了该领域面临的需求和挑战，以提供一个有助于阐明表观遗传学在童年不良经历长期影响中作用的框架。
