Metrailer Georgette, Tavares Karina, Pault Mikayla Ver, Lopez Adamari, Denherder Shane, Hernandez Valencia Everlyn, DiMarzio Karissa, Highlander April, Merrill Sarah M, Rojo-Wissar Darlynn M, Parent Justin
Alpert Medical School of Brown University, Providence, RI.
University of Rhode Island, Kingston, RI.
medRxiv. 2025 Jan 16:2024.12.23.24319484. doi: 10.1101/2024.12.23.24319484.
Early Life Adversity (ELA) has been linked to accelerated epigenetic aging. While positive parenting is hypothesized to buffer the detrimental effects of ELA on child development, its role in mitigating epigenetic age acceleration remains unclear. Data from 2,039 children (49.7% female) in the Future of Families and Child Wellbeing Study (FFCWS) were included in the current study (46.7% Black, 26.5% Hispanic, 19% White non-Hispanic). Home and community threat and observed parenting were measured from ages 3 to 9. Salivary epigenetic age acceleration was measured at ages 9 and 15. Positive parenting reduces the pace of epigenetic aging in low, but not high, community-threat environments. Interventions across home and community environments may be necessary to prevent ELA's biological embedding.
早年生活逆境（ELA）与表观遗传衰老加速有关。虽然积极育儿被认为可以缓冲ELA对儿童发育的有害影响，但其在减轻表观遗传年龄加速方面的作用仍不明确。本研究纳入了来自家庭与儿童福祉未来研究（FFCWS）的2039名儿童（49.7%为女性）的数据（46.7%为黑人，26.5%为西班牙裔，19%为非西班牙裔白人）。从3岁到9岁对家庭和社区威胁以及观察到的育儿情况进行了测量。在9岁和15岁时测量了唾液表观遗传年龄加速情况。在社区威胁程度低但非高的环境中，积极育儿可减缓表观遗传衰老的速度。可能需要在家庭和社区环境中进行干预，以防止ELA在生物学上的嵌入。
