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脊髓损伤患者下肢骨折手术治疗后的临床及影像学结果

Clinical and Radiological Outcomes After Surgical Treatment of Lower Limb Fractures in Patients With Spinal Cord Injury.

作者信息

Ung Lars, Ohlmeier Malte, Jettkant Birger, Grasmücke Dennis, Aach Mirko, Meindl Renate, Nicolas Volkmar, Schildhauer Thomas A, Citak Mustafa

机构信息

BG-University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany.

出版信息

Global Spine J. 2020 Sep;10(6):715-719. doi: 10.1177/2192568219871019. Epub 2019 Aug 19.

Abstract

STUDY DESIGN

Retrospective observational study.

OBJECTIVES

To analyze the clinical and radiological outcomes of lower limb fractures following surgical treatment in patients with chronic spinal cord injury (SCI).

METHODS

Between January 2003 and December 2015, 102 chronic SCI patients with a lower limb fracture were surgically treated at our hospital. A total of 58 patients met the inclusion criteria and were recruited for final analysis. Patients with 2-stage procedure or incomplete clinical records with lost-to-follow-up were excluded from the study. Patients were divided into 2 groups (group 1= internal fixation; group 2 = external fixation). Primary outcome measures were to identify the number of nonunions via Kaplan-Meier analysis and the time to bone consolidation. The diagnosis of a pseudarthrosis was made after more than 180 days of consolidation time. Considering the Kaplan-Meier analysis, pseudarthrosis was interpreted as treatment failure. Secondary outcome measure was to evaluate the complication rate with special focus on heterotopic ossification.

RESULTS

A total of 58 chronic SCI patients with closed bone fractures were included in this study. Fifty-two fractures (88%) were simple and 7 (12%) were complex (type C) fractures according to AO classification. The majority of patients (34 cases, 59%) developed femur fractures followed by 24 tibial fractures (41%). Seventeen patients received an external (29%) and 41 an internal fixation (71%). Bone consolidation was reported in 31 patients (53%) with a mean time interval of bone consolidation after 97 days (range from 45 to 160 days; SD = 30). The reported nonunion (pseudarthrosis) rate was 47%. Comparing the internal group (n = 15 patients) versus the external group (n = 14), we could not find any significant difference ( = .939) concerning the bone consolidation time. The Kaplan-Meier analysis showed a 75% cumulative survivorship at 120 days (internal group) versus 111 days (external group). Most common postoperative complications occurred in the internal fixation group with Wound infections being predominantly observed (10%), followed by heterotopic ossifications (8%).

CONCLUSIONS

Our results show that surgical treatment of lower limb fractures in chronic SCI patients is a challenging treatment with a high pseudarthrosis rate in both groups. The complication rate seems to be lower in the patients treated with external fixation. As a clinical recommendation, longer implants should be used for a stable osteosynthesis since SCI patients seem to have a higher load on the osteosynthesis material due to missing sensomotoric feedback.

摘要

研究设计

回顾性观察性研究。

目的

分析慢性脊髓损伤(SCI)患者下肢骨折手术治疗后的临床和影像学结果。

方法

2003年1月至2015年12月期间,我院对102例慢性SCI合并下肢骨折患者进行了手术治疗。共有58例患者符合纳入标准并被纳入最终分析。排除接受两阶段手术或临床记录不完整且失访的患者。患者分为两组(第1组=内固定;第2组=外固定)。主要结局指标是通过Kaplan-Meier分析确定骨不连的数量以及骨愈合时间。在愈合时间超过180天后诊断为假关节。考虑到Kaplan-Meier分析,假关节被解释为治疗失败。次要结局指标是评估并发症发生率,特别关注异位骨化。

结果

本研究共纳入58例慢性SCI合并闭合性骨折患者。根据AO分类,52处骨折(88%)为简单骨折,7处(12%)为复杂(C型)骨折。大多数患者(34例,59%)发生股骨骨折,其次是24例胫骨骨折(41%)。17例患者接受外固定(29%),41例接受内固定(71%)。31例患者(53%)报告骨愈合,骨愈合的平均时间间隔为97天(范围为45至160天;标准差=30)。报告的骨不连(假关节)率为47%。比较内固定组(n = 15例患者)和外固定组(n = 14例),我们发现骨愈合时间没有显著差异(P = 0.939)。Kaplan-Meier分析显示,内固定组120天时的累积生存率为75%,外固定组为111天。最常见的术后并发症发生在内固定组,主要观察到伤口感染(10%),其次是异位骨化(8%)。

结论

我们的结果表明,慢性SCI患者下肢骨折的手术治疗是一项具有挑战性的治疗,两组的假关节率都很高。外固定治疗的患者并发症发生率似乎较低。作为一项临床建议,由于SCI患者似乎因缺乏感觉运动反馈而对骨合成材料的负荷更高,因此应使用更长的植入物进行稳定的骨合成。

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