早期肠道微生物组可能有助于预防早产儿重度视网膜病变。
The early gut microbiome could protect against severe retinopathy of prematurity.
机构信息
Department of Ophthalmology, University of Chicago, Chicago, Illinois; Microbiome Center, University of Chicago, Chicago, Illinois.
Department of Ophthalmology, University of Chicago, Chicago, Illinois.
出版信息
J AAPOS. 2020 Aug;24(4):236-238. doi: 10.1016/j.jaapos.2020.03.010. Epub 2020 Jul 21.
Abstract
In this study, 6 infants with type 1 retinopathy of prematurity (ROP) were compared with 4 high-risk preterm neonates without any ROP but similar baseline neonatal comorbidities. The infants with type-1 ROP showed significant enrichment of Enterobacteriaceae at 28 weeks' postmenstrual age. Several metabolic pathways, including several amino acid metabolism pathways, were enriched in gut microbiota of infants without ROP. Based on these findings, we posit a possible association between early gut microbiome profile and ROP pathogenesis. Furthermore, it is possible that absence of Enterobacteriaceae overabundance, in addition to enrichment of amino acid biosynthesis pathways, may protect against severe ROP in high-risk preterm infants.
摘要
在这项研究中，将 6 名患有 1 型早产儿视网膜病变（ROP）的婴儿与 4 名患有相似基线新生儿合并症但无任何 ROP 的高危早产儿进行了比较。患有 1 型 ROP 的婴儿在 28 周龄时表现出肠杆菌科的显著富集。在没有 ROP 的婴儿的肠道微生物群中，包括几种氨基酸代谢途径在内的几种代谢途径都得到了富集。基于这些发现，我们假设早期肠道微生物组特征与 ROP 发病机制之间可能存在关联。此外，除了氨基酸生物合成途径的富集外，肠杆菌科的过度生长缺失也可能保护高危早产儿免受严重 ROP 的侵害。
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本文引用的文献
1
The microbiome and ophthalmic disease.微生物组与眼科疾病。
Exp Biol Med (Maywood). 2019 Apr;244(6):419-429. doi: 10.1177/1535370218813616. Epub 2018 Nov 21.
2
Retinopathy of prematurity: a review of risk factors and their clinical significance.早产儿视网膜病变：危险因素及其临床意义综述。
Surv Ophthalmol. 2018 Sep-Oct;63(5):618-637. doi: 10.1016/j.survophthal.2018.04.002. Epub 2018 Apr 19.
3
Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice.肠道微生物群对人源化无菌小鼠大脑发育的影响。
Sci Rep. 2018 Apr 3;8(1):5443. doi: 10.1038/s41598-018-23692-w.
4
Association of the Intestinal Microbiome with the Development of Neovascular Age-Related Macular Degeneration.肠道微生物组与新生血管性年龄相关性黄斑变性发展的关联。
Sci Rep. 2017 Jan 17;7:40826. doi: 10.1038/srep40826.
5
Up-regulation of intestinal vascular endothelial growth factor by Afa/Dr diffusely adhering Escherichia coli.Afa/Dr弥漫黏附性大肠杆菌对肠道血管内皮生长因子的上调作用
PLoS One. 2007 Dec 26;2(12):e1359. doi: 10.1371/journal.pone.0001359.
6
Glucose and amino acids interact with hormones to control expression of insulin-like growth factor-I and growth hormone receptor mRNA in cultured pig hepatocytes.葡萄糖和氨基酸与激素相互作用，以控制培养的猪肝细胞中胰岛素样生长因子-I和生长激素受体mRNA的表达。
J Nutr. 1999 Jul;129(7):1298-306. doi: 10.1093/jn/129.7.1298.
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