State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Hwa Chong Institution (College), 661 Bukit Timah Road, Singapore 269734, Singapore.
Int J Biol Macromol. 2020 Dec 1;164:884-891. doi: 10.1016/j.ijbiomac.2020.07.191. Epub 2020 Jul 22.
MUC2 mucin is an important secretory protein found in the human gut. Recent studies indicated that MUC2 mucin plays a role in the protection of gut barrier, the regulation of microbiome homeostasis and the prevention of diseases. In this review, the physiological properties of MUC2 mucin and its interactions with the intestinal microbiome are firstly discussed. Its roles in intestinal diseases including inflammatory bowel disease, colorectal cancer and parasitic infections are concluded. We also reviewed dietary components known to have modulative effects on MUC2 mucin expression, such as polysaccharides, amino acids and polyphenols.
黏蛋白 MUC2 是一种在人体肠道中发现的重要分泌蛋白。最近的研究表明，黏蛋白 MUC2 在保护肠道屏障、调节微生物组稳态和预防疾病方面发挥着作用。在这篇综述中，首先讨论了黏蛋白 MUC2 的生理特性及其与肠道微生物组的相互作用。总结了它在包括炎症性肠病、结直肠癌和寄生虫感染等肠道疾病中的作用。我们还回顾了已知对黏蛋白 MUC2 表达具有调节作用的膳食成分，如多糖、氨基酸和多酚。
