PEG-8 Laurate Fermentation of Reduces the Required Dose of Clindamycin Against .

The probiotic activity of skin () bacteria can elicit diverse biological functions via the fermentation of various carbon sources. Here, we found that polyethylene glycol (PEG)-8 Laurate, a carbon-rich molecule, can selectively induce the fermentation of , not (), a bacterium associated with acne vulgaris. The PEG-8 Laurate fermentation of remarkably diminished the growth of and the -induced production of pro-inflammatory macrophage-inflammatory protein 2 (MIP-2) cytokines in mice. Fermentation media enhanced the anti- activity of a low dose (0.1%) clindamycin, a prescription antibiotic commonly used to treat acne vulgaris, in terms of the suppression of colonization and MIP-2 production. Furthermore, PEG-8 Laurate fermentation of boosted the activity of 0.1% clindamycin to reduce the sizes of colonies. Our results demonstrated, for the first time, that the PEG-8 Laurate fermentation of displayed the adjuvant effect on promoting the efficacy of low-dose clindamycin against . Targeting by lowering the required doses of antibiotics may avoid the risk of creating drug-resistant and maintain the bacterial homeostasis in the skin microbiome, leading to a novel modality for the antibiotic treatment of acne vulgaris.