Papaevangelou G, Halstead S B
J Trop Med Hyg. 1977 Mar;80(3):46-51.
From contemporary clinical accounts we hypothesized that the 1928 dengue epidemic in Greece may have been an earlier occurrence of dengue hemorrhagic fiver/dengue shock syndrome (DHF/DSS). To study the possibility that two different dengue viruses may have been involved, serums from 62 Athenians alive during the epidemic were examined for dengue antibodies; 73 per cent showed evidence of prior dengue infection. Monotypic neutralizing antibodies were found to two different dengue viruses, types 1 and 2. A large proportion of the sampled population had evidence of two or more past dengue infections. Since there is no evidence that dengue viruses have been transmitted in Greece since 1928, during the epidemic a very large number of persons immune to one dengue type must have acquired infections with a secon type. The virological criteria for secondary infection DHF/DSS are thus satisfied. Although DHF/DSS is currently restricted to Asia and the Pacific, the Greek oubreak suggests a biological potential for fatal consequences of dengue infections in Caucasians, particularly the elderly.
根据当代临床记录，我们推测1928年希腊的登革热疫情可能是登革出血热/登革休克综合征（DHF/DSS）的早期病例。为了研究是否涉及两种不同的登革热病毒，我们检测了疫情期间仍在世的62名雅典人的血清中的登革热抗体；73%的人有既往登革热感染的证据。发现了针对两种不同登革热病毒（1型和2型）的单型中和抗体。很大一部分抽样人群有两次或更多次既往登革热感染的证据。由于没有证据表明自1928年以来登革热病毒在希腊传播，在疫情期间，大量对一种登革热病毒免疫的人肯定感染了另一种病毒。因此，二次感染DHF/DSS的病毒学标准得到了满足。尽管目前DHF/DSS仅限于亚洲和太平洋地区，但希腊的疫情表明，登革热感染对高加索人，尤其是老年人可能产生致命后果。
