糖尿病对胆囊癌患者生存的影响：系统评价和荟萃分析。
Effect of diabetes mellitus on survival in patients with gallbladder Cancer: a systematic review and meta-analysis.
机构信息
School of Nursing and Health, Nanfang College of Sun Yat-sen University, Guangzhou, 510970, Guangdong Province, China.
出版信息
BMC Cancer. 2020 Jul 24;20(1):689. doi: 10.1186/s12885-020-07139-y.
BACKGROUND
Increasing evidences indicated that diabetes might increase the incidence of gallbladder cancer. However, no sufficient data has ever clarified the impact of diabetes on the survival of patients with gallbladder cancer.
METHODS
We comprehensively searched PubMed, Embase, and the Cochrane Library databases through July 2019 in order to find sufficient eligible researches. The pooled hazard risks (HRs) and relative risks (RRs) with 95% confidence intervals (CIs) were calculated with either fix-effects or random-effects model. Due to the low gallbladder cancer mortality in general population, the RRs and standard mortality ratios (SMRs) were considered the similar estimates of the HRs.
RESULTS
Ten eligible studies were included in this meta-analysis. Analysis of eight cohorts found that diabetes was closely associated with the mortality of gallbladder cancer (HR = 1.10; 95% CI: 1.06-1.14; P < 0.00001). However, the mortality in male diabetes patients was not higher than female patients (RR = 1.08, 95%CI = 0.57-2.04, P = 0.80).
CONCLUSIONS
These findings indicated that diabetes patients had a higher mortality of gallbladder cancer compared with non-diabetes.
背景
越来越多的证据表明糖尿病可能会增加胆囊癌的发病率。然而，尚无充分的数据阐明糖尿病对胆囊癌患者生存的影响。
方法
我们全面检索了 PubMed、Embase 和 Cochrane Library 数据库，截至 2019 年 7 月，以查找充分的合格研究。使用固定效应或随机效应模型计算合并的风险比（HRs）和相对风险（RRs）及其 95%置信区间（CIs）。由于总体人群的胆囊癌死亡率较低，RRs 和标准化死亡率比（SMRs）被认为是 HRs 的相似估计值。
结果
本荟萃分析纳入了 10 项合格研究。对 8 项队列研究的分析表明，糖尿病与胆囊癌的死亡率密切相关（HR=1.10；95%CI：1.06-1.14；P<0.00001）。然而，男性糖尿病患者的死亡率并不高于女性患者（RR=1.08，95%CI=0.57-2.04，P=0.80）。
结论
这些发现表明，与非糖尿病患者相比，糖尿病患者的胆囊癌死亡率更高。
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