Biomedical Research Laboratories, Catholic University of Maule, Talca 34600000, Maule, Chile.
Medicine Faculty, Catholic University of Maule, Talca 34600000, Maule, Chile.
World J Gastroenterol. 2022 Oct 21;28(39):5679-5690. doi: 10.3748/wjg.v28.i39.5679.
Compelling evidence derived from clinical and experimental research has demonstrated the crucial contribution of chronic inflammation in the development of neoplasms, including gallbladder cancer. In this regard, data derived from clinical and experimental studies have demonstrated that the receptor of advanced glycation end-products (RAGE)/AGEs axis plays an important role in the onset of a crucial and long-lasting inflammatory milieu, thus supporting tumor growth and development. AGEs are formed in biological systems or foods, and food-derived AGEs, also known as dietary AGEs are known to contribute to the systemic pool of AGEs. Once they bind to RAGE, the activation of multiple and crucial signaling pathways are triggered, thus favoring the secretion of several proinflammatory cytokines also involved in the promotion of gallbladder cancer invasion and migration. In the present review, we aimed to highlight the relevance of the association between high dietary AGEs intakes and high risk for gallbladder cancer, and emerging data supporting that dietary intervention to reduce gallbladder cancer risk is a very attractive approach that deserves much more research efforts.
来自临床和实验研究的有力证据表明，慢性炎症在肿瘤的发展中起着关键作用，包括胆囊癌。在这方面，来自临床和实验研究的数据表明，晚期糖基化终产物受体（RAGE）/AGEs 轴在引发关键和持久的炎症环境中起着重要作用，从而支持肿瘤的生长和发展。AGEs 在生物系统或食物中形成，并且食物来源的 AGEs，也称为膳食 AGEs，已知会导致全身 AGEs 池的增加。一旦它们与 RAGE 结合，就会触发多个关键信号通路的激活，从而有利于几种促炎细胞因子的分泌，这些细胞因子也参与了胆囊癌的侵袭和迁移的促进。在本综述中，我们旨在强调高膳食 AGEs 摄入与胆囊癌高风险之间的相关性的重要性，以及支持饮食干预以降低胆囊癌风险的新出现的数据，这是一种非常有吸引力的方法，值得进一步研究。
