Robson Kate J, Kitching A Richard
Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia.
Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia; Department of Nephrology, Monash Health, Clayton, Victoria, Australia; Department of Pediatric Nephrology, Monash Health, Clayton, Victoria, Australia.
Kidney Int. 2020 Aug;98(2):280-283. doi: 10.1016/j.kint.2020.04.026.
Tertiary lymphoid tissues are peripheral foci of immune activity that develop in kidneys and other peripheral organs in the context of chronic inflammation. In this issue of Kidney International, Sato and colleagues present a detailed characterization of tertiary lymphoid tissues in mouse and human kidneys in the context of acute kidney injury, chronic pyelonephritis, aging, and chronic kidney disease, showing the importance of nontraditional roles of B cells in the inflamed kidney microenvironment.
三级淋巴组织是在慢性炎症情况下于肾脏和其他外周器官中形成的外周免疫活性病灶。在本期《国际肾脏病杂志》中，佐藤及其同事详细描述了急性肾损伤、慢性肾盂肾炎、衰老和慢性肾脏病背景下小鼠和人肾脏中三级淋巴组织的特征，揭示了B细胞在炎症性肾脏微环境中的非传统作用的重要性。
