Qilu University of Technology (Shandong Academy of Sciences), Shandong Analysis and Test Center, Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Jinan 250014, China; College of Food Science and Engineering, Shandong Agricultural University, Taian 271018, China.
Qilu University of Technology (Shandong Academy of Sciences), Shandong Analysis and Test Center, Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Jinan 250014, China.
J Chromatogr A. 2020 Aug 16;1625:461275. doi: 10.1016/j.chroma.2020.461275. Epub 2020 May 29.
Efficient extraction of polar sulfonamides antibiotics from aqueous samples and food is very challenging, because they are hydrophilic, their concentration is very low, and the matrix is complex. Covalent organic frameworks (COFs), a novel porous organic material, have attracted great attention. In this work, the spherical triphenylbenzene-dimethoxyterephthaldehyde-COFs (TPB-DMTP-COFs) were synthesized by a simple room temperature method, and due to their attractive properties, such as high outstanding acid-base stability, large specific surface area, low skeletal density, inherent porosity and high crystallinity, so TPB-DMTP-COFs as ideal solid phase extraction adsorbents showed excellent adsorption performance for trace polar sulfonamides in food and water. TPB-DMTP-COFs were characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, powder X-ray diffraction, and so on. The important parameters were optimized to improve the extraction efficiency of TPB-DMTP-COFs toward sulfonamides. Analysis of sulfonamides was performed by liquid chromatography-tandem mass spectrometry. The developed method based on TPB-DMTP-COFs material achieved low limits of detection (0.5-1.0 ng L), wide linearity (5-1000 ng L), and good repeatability (2.5%-8.7%). The possible extraction mechanism was also discussed. Finally, the method was successfully applied to the enrichment and detection of sulfonamides in environmental water samples and food samples. The present study indicated that TPB-DMTP-COFs had splendid prospects in highly sensitive analysis of other pollutants in complex matrix.
从水样和食品中高效提取极性磺酰胺类抗生素非常具有挑战性，因为它们具有亲水性，浓度非常低，且基质复杂。共价有机骨架（COFs）是一种新型多孔有机材料，引起了极大的关注。在这项工作中，通过简单的室温方法合成了球形三苯并苯-二甲氧基对苯二甲酸 COFs（TPB-DMTP-COFs），由于其具有出色的酸碱稳定性、大的比表面积、低的骨架密度、固有孔隙率和高结晶度等吸引人的特性，因此 TPB-DMTP-COFs 作为理想的固相萃取吸附剂，对食品和水中痕量极性磺酰胺类抗生素表现出优异的吸附性能。通过扫描电子显微镜、傅里叶变换红外光谱、粉末 X 射线衍射等对 TPB-DMTP-COFs 进行了表征。优化了重要参数以提高 TPB-DMTP-COFs 对磺酰胺类的萃取效率。通过液相色谱-串联质谱法对磺酰胺类进行分析。基于 TPB-DMTP-COFs 材料开发的方法实现了低检测限（0.5-1.0ngL）、宽线性范围（5-1000ngL）和良好的重复性（2.5%-8.7%）。还讨论了可能的提取机制。最后，该方法成功应用于环境水样和食品样品中磺酰胺类的富集和检测。本研究表明，TPB-DMTP-COFs 在复杂基质中其他污染物的高灵敏度分析方面具有广阔的前景。
