College of Veterinary Medicine, South China Agricultural University, Guangzhou, P. R. China.
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, P. R. China.
J Sep Sci. 2024 Jan;47(1):e2300535. doi: 10.1002/jssc.202300535. Epub 2023 Nov 7.
In this article, a highly crystalline porous imine-based covalent organic framework was synthesized at room temperature and used as solid-phase extraction (SPE) adsorbent for the purification and enrichment of trace sulfonamides (SAs) from food samples. The structure of the obtained material was characterized and studied in detail. The extraction process was optimized and the final elution was determined by the ultra-high-performance liquid chromatography-quadrupole time of flight mass spectrometry method. Low limits of detection (0.02-0.19 μg/kg) were obtained under optimal conditions, with the recoveries ranging from 70.5% to 105.3% when spiked at different levels. The adsorption process of the material for SAs was fitted by the Langmuir and Freundlich adsorption isotherm model, and the extraction capacity for Nitrofuran metabolites from food samples was also investigated for comparison. The results demonstrated that the framework was a good candidate SPE adsorbent that can be used for the enrichment of drug residues in complex matrix, and the work may provide a systematic study method for the development of porous adsorbents.
本文在室温下合成了一种高结晶多孔亚胺基共价有机骨架，并将其用作固相萃取（SPE）吸附剂，用于从食品样品中纯化和富集痕量磺胺类药物（SAs）。详细表征和研究了所得材料的结构。优化了萃取工艺，并通过超高效液相色谱-四极杆飞行时间质谱法确定了最终洗脱液。在最佳条件下，可获得低检测限（0.02-0.19μg/kg），当在不同水平下进行加标时，回收率在 70.5%至 105.3%之间。通过 Langmuir 和 Freundlich 吸附等温线模型拟合了材料对 SAs 的吸附过程，并比较了其从食品样品中萃取硝基呋喃代谢物的能力。结果表明，该骨架是一种良好的 SPE 吸附剂候选材料，可用于复杂基质中药物残留的富集，该工作可能为多孔吸附剂的开发提供系统的研究方法。
