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Vernal keratoconjunctivitis in human immunodeficiency virus - The possible role of T-helper 1-T-helper 2 shift.人免疫缺陷病毒相关性春季角结膜炎:辅助性 T 细胞 1 型向辅助性 T 细胞 2 型漂移的可能作用。
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Management of vernal keratoconjunctivitis.春季角结膜炎的治疗。
Ophthalmol Ther. 2013 Dec;2(2):73-88. doi: 10.1007/s40123-013-0019-y. Epub 2013 Sep 7.
3
Pathogenesis of Vernal Keratoconjunctivitis and Associated Factors.春季角结膜炎的发病机制及相关因素
Semin Ophthalmol. 2015;30(5-6):340-4. doi: 10.3109/08820538.2013.874483. Epub 2014 Feb 27.
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Vernal keratoconjunctivitis: a severe allergic eye disease with remodeling changes.春季角结膜炎:一种伴有重塑改变的严重过敏性眼部疾病。
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J Allergy Clin Immunol. 2014 Feb;133(2):589-91. doi: 10.1016/j.jaci.2013.08.037. Epub 2013 Oct 15.
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Demographic and clinical profile of vernal keratoconjunctivitis at a tertiary eye care center in India.印度一家三级眼科保健中心的春季角结膜炎的人口统计学和临床特征。
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Vernal keratoconjunctivitis: atopy and autoimmunity.春季角结膜炎:过敏和自身免疫。
Eur Rev Med Pharmacol Sci. 2013 May;17(10):1419-23.
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Ocular manifestation of HIV/AIDS and correlation with CD4+ cells count among adult HIV/AIDS patients in Jimma town, Ethiopia: a cross sectional study.埃塞俄比亚吉姆马镇成人 HIV/AIDS 患者的眼部表现与 CD4+ 细胞计数的相关性:一项横断面研究。
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Vernal keratoconjunctivitis-like disease in adults.成人春季角结膜炎样疾病。
Am J Ophthalmol. 2013 May;155(5):796-803. doi: 10.1016/j.ajo.2012.11.018. Epub 2013 Jan 23.
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Systemic atopy and immunoglobulin deficiency in Turkish patients with vernal keratoconjunctivitis.土耳其春季角结膜炎患者的系统性过敏和免疫球蛋白缺乏。
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人类免疫缺陷病毒在成人春季角结膜炎样疾病发病机制中的作用:一项人口统计学和流行病学研究。

The role of human immunodeficiency virus in the pathogenesis of vernal keratoconjunctivitis-like disease in adults: A demographic and epidemiological study.

作者信息

Kritzinger Anine, Zaborowski Anthony G, Sibanda Wilbert, Visser Linda

机构信息

Department of Ophthalmology, University of KwaZulu-Natal, Durban, South Africa.

School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Durban, South Africa.

出版信息

Indian J Ophthalmol. 2020 Aug;68(8):1551-1554. doi: 10.4103/ijo.IJO_1608_19.

DOI:10.4103/ijo.IJO_1608_19
PMID:32709773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7640813/
Abstract

PURPOSE

The purpose was to identify and describe patients with new-onset vernal keratoconjunctivitis-like (VKC-like) disease after puberty.

METHODS

The study consisted of two parts: a prospective observational descriptive study of patients with new-onset VKC-like disease, and a case-control study to determine the relationship of a CD4 count with VKC-like disease in adults, in the setting of human immunodeficiency virus (HIV). Patients were recruited between January 2016 and November 2017 from a Provincial Eye hospital, one of two large referral hospitals in KwaZulu-Natal, South Africa. Patients presenting to the eye clinic were screened and diagnosed at the Primary Eye Care Unit. Inclusion criteria: age 15 years and older with signs and symptoms of new-onset VKC-like disease. Exclusion criteria: a history of childhood atopic diseases, atopic keratoconjunctivitis and patients who declined HIV testing. Data collected included HIV status, CD4 count, antinuclear antibodies and total serum immunoglobulin E.

RESULTS

Thirty-three patients were included; females n = 16 and males n = 17. The mean age at presentation was 32.45 ± 9.93 years, 95% CI = 28.94-35.97. Twenty-six patients (78.8%) were HIV positive, 95% CI (62-89). The proportion of HIV positive patients was statistically different from the HIV negative group, Chi-squared = 21.866, P value <0.0001. In the group of HIV positive patients, 72% were classified as immunodeficient according to their CD4 counts. An association was proven between severely immunodeficient patients and the risk of VKC-like disease (Chi-squared = 4.992, P value = 0.0255).

CONCLUSION

In this cohort, a statistically significant association was found between VKC-like disease in adults and an HIV positive status. This association calls for more research on the subject.

摘要

目的

本研究旨在识别并描述青春期后新发的类春季角结膜炎(VKC 样)疾病患者。

方法

本研究包括两个部分:对新发 VKC 样疾病患者进行前瞻性观察性描述性研究,以及在人类免疫缺陷病毒(HIV)感染背景下进行病例对照研究,以确定 CD4 细胞计数与成人 VKC 样疾病之间的关系。2016 年 1 月至 2017 年 11 月期间,从南非夸祖鲁 - 纳塔尔省的两家大型转诊医院之一的省级眼科医院招募患者。在初级眼科护理单元对到眼科门诊就诊的患者进行筛查和诊断。纳入标准:年龄 15 岁及以上,有新发 VKC 样疾病的体征和症状。排除标准:有儿童期特应性疾病、特应性角结膜炎病史以及拒绝进行 HIV 检测的患者。收集的数据包括 HIV 状态、CD4 细胞计数、抗核抗体和血清总免疫球蛋白 E。

结果

共纳入 33 例患者;女性 16 例,男性 17 例。就诊时的平均年龄为 32.45±9.93 岁,95%置信区间 = 28.94 - 35.97。26 例患者(78.8%)HIV 呈阳性,95%置信区间(62 - 89)。HIV 阳性患者的比例与 HIV 阴性组在统计学上存在差异,卡方值 = 21.866,P 值 <0.0001。在 HIV 阳性患者组中,根据 CD4 细胞计数,72%被归类为免疫缺陷。严重免疫缺陷患者与 VKC 样疾病风险之间存在关联(卡方值 = 4.992,P 值 = 0.0255)。

结论

在该队列中,发现成人 VKC 样疾病与 HIV 阳性状态之间存在统计学上的显著关联。这种关联需要对该主题进行更多研究。