Agarwal Shweta, Srinivasan Bhaskar, Iyer Geetha, Patel Nilay, Rajagopal Rama, Gurumurthy Srividya, Sudharshan Sridharan
CJ Shah Cornea Services/Dr G Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Medical Research Foundation, Chennai, Tamil Nadu, India.
SN-SANMAR Center of Excellence for SJS, Medical Research Foundation, Chennai, Tamil Nadu, India.
Indian J Ophthalmol. 2025 Apr 1;73(4):599-602. doi: 10.4103/IJO.IJO_2314_24. Epub 2025 Mar 27.
To analyze the clinical profile of vernal keratoconjunctivitis (VKC) and its response to treatment in human immunodeficiency virus (HIV) patients and its relation with CD4 counts.
This study is a retrospective observational case series of patients with HIV and VKC.
Thirteen patients presented with HIV and VKC, with 69.2% having a severe-grade VKC. Median age of onset of VKC was 5 years in children and 31.5 years in adults. Seventy percent had a drop in CD4 counts at the onset of VKC. The duration between diagnosis of HIV and onset of VKC was statistically less in adults than in children. Eleven were on highly active antiretroviral therapy at presentation, and three patients were changed to second line of therapy, two of whom showed worsening of VKC just before shifting.
The study thus highlights the correlation between worsening of VKC and decrease in CD4 counts, and thus there is a need for aggressive management of HIV to prevent VKC-related complications.
分析人类免疫缺陷病毒（HIV）患者春季角结膜炎（VKC）的临床特征、其对治疗的反应及其与CD4细胞计数的关系。
本研究是一项关于HIV和VKC患者的回顾性观察病例系列研究。
13例患者患有HIV和VKC，其中69.2%为重度VKC。儿童VKC发病的中位年龄为5岁，成人为31.5岁。70%的患者在VKC发病时CD4细胞计数下降。成人从HIV诊断到VKC发病的时间在统计学上比儿童短。11例患者在就诊时接受高效抗逆转录病毒治疗，3例患者改为二线治疗，其中2例在换药前VKC病情恶化。
该研究突出了VKC病情恶化与CD4细胞计数下降之间的相关性，因此需要积极治疗HIV以预防VKC相关并发症。
