Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Shanghai, China.
Methods Mol Biol. 2020;2204:99-107. doi: 10.1007/978-1-0716-0904-0_9.
Epstein-Barr virus (EBV) is a B-lymphocytes herpes virus and can transform B lymphocytes to malignant tumor cells if infected. Nasopharyngeal carcinoma (NPC) is strongly associated with EBV. Circulating EBV DNA in plasma has been recognized as an important biomarker of NPC. Much work has been done to validate the ability of circulating EBV DNA for screening, diagnosis, risk stratification, monitoring, and predicting prognosis. This chapter reviews the clinical progress of circulating cell-free EBV DNA in NPC.
EB 病毒（EBV）是一种 B 淋巴细胞疱疹病毒，如果感染，它可以将 B 淋巴细胞转化为恶性肿瘤细胞。鼻咽癌（NPC）与 EBV 密切相关。血浆中循环 EBV DNA 已被认为是 NPC 的一个重要生物标志物。已经做了很多工作来验证循环细胞游离 EBV DNA 在 NPC 中的筛查、诊断、风险分层、监测和预后预测能力。本章综述了 NPC 中循环游离 EBV DNA 的临床进展。
