播散性新生儿单纯疱疹病毒感染伴坏死性脑炎——1例尸检病例
Disseminated neonatal herpes simplex virus infection with necrotizing encephalitis--an autopsy case.
作者信息
Suh Y L, Kim H, Chi J G, Byun H R, Lee K
机构信息
Department of Pathology, Seoul National University Children's Hospital, Seoul, Korea.
出版信息
J Korean Med Sci. 1987 Jun;2(2):123-7. doi: 10.3346/jkms.1987.2.2.123.
An autopsy case of disseminated HSV type 2 infection occurring in a neonate at 32 weeks' gestation, delivered by cesarean section after premature rupture of membrane of 7 days duration, is presented. Herpes simplex virus type 2 was isolated from the vesicular skin lesion. The mother and patient had specific antibody to type 2 herpes simplex virus. Patient's parents had denied any herpetic orolabial or genital lesion during or before this pregnancy. Cultures from the cervical and vaginal swabs of the mother were negative for HSV. Postmortem examination showed hepatic necrosis, skin vesicle, devastating necrotizing inflammation of the brain, chorioretinitis and interstitial pneumonitis.
本文报告一例妊娠32周新生儿播散性2型单纯疱疹病毒（HSV）感染的尸检病例。该新生儿在胎膜早破7天后经剖宫产娩出。从水疱性皮肤损害中分离出2型单纯疱疹病毒。母亲和患儿均有2型单纯疱疹病毒特异性抗体。患儿父母否认此次妊娠期间及之前有任何疱疹性口唇或生殖器损害。母亲宫颈和阴道拭子培养未检测到HSV。尸检显示肝坏死、皮肤水疱、严重的脑坏死性炎症、脉络膜视网膜炎和间质性肺炎。
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