Department of Neonatology, St. Bernward Hospital Hildesheim, Treibestrasse 9, 31134 Hildesheim, Germany.
J Clin Virol. 2012 Jul;54(3):269-71. doi: 10.1016/j.jcv.2012.03.005. Epub 2012 Apr 1.
Genital herpes, usually caused by herpes simplex virus type 2 (HSV-2), is one of the most common sexually transmitted diseases in humans. By contrast, intrauterine HSV-2 infections have been described rarely in the literature. Our report describes a case of neonate who was delivered after 30+2 gestational weeks by cesarean section. He presented with a respiratory distress syndrome resulting in broncho-pulmonary dysplasia. At the age of 6 weeks, a chorioretinal scar was detected. During the 4th month of age, the infant developed recurrent HSV-2 infection with nasal lesions. The retrospective type-specific serologic diagnosis revealed previous HSV-2 infection of the mother resulting in prenatal HSV-2 infection of the infant. In conclusion, intrauterine HSV-2 infections may be underrepresented since they may not be associated with severe congenital malformations and the diagnosis requires the use of HSV type-specific serologic methods not widely applied in microbiological laboratories.
生殖器疱疹通常由单纯疱疹病毒 2 型（HSV-2）引起，是人类最常见的性传播疾病之一。相比之下，文献中很少描述宫内 HSV-2 感染。我们的报告描述了一例新生儿，他在 30+2 孕周时通过剖宫产分娩。他患有呼吸窘迫综合征，导致支气管肺发育不良。在 6 周大时，发现了脉络膜视网膜瘢痕。在 4 月龄时，婴儿出现了复发性 HSV-2 感染，伴有鼻腔病变。回顾性的特定类型血清学诊断显示，母亲先前的 HSV-2 感染导致婴儿宫内 HSV-2 感染。总之，宫内 HSV-2 感染可能被低估了，因为它们可能与严重的先天性畸形无关，而且诊断需要使用 HSV 特定类型的血清学方法，而这些方法在微生物学实验室中尚未广泛应用。
