School of Biological and Chemical Engineering, Panzhihua University, Panzhihua, PR China.
School of Life Sciences, Shandong University of Technology, Zibo, PR China.
Biotechnol Adv. 2020 Nov 1;43:107602. doi: 10.1016/j.biotechadv.2020.107602. Epub 2020 Jul 22.
Although biotechnologies for astaxanthin production from Haematococcus pluvialis have been developed for decades and many production facilities have been established throughout the world, the production cost is still high. This paper is to evaluate the current production processes and production facilities, to analyze the R&D strategies for process improvement, and to review the recent research advances shedding light on production cost reduction. With these efforts being made, we intent to conclude that the production cost of astaxanthin from Haematococcus might be substantially reduced to the levels comparable to that of chemical astaxanthin through further R&D and the future research might need to focus on strain selection and improvement, cultivation process optimization, innovation of cultivation methodologies, and revolution of extraction technologies.
尽管从雨生红球藻生产虾青素的生物技术已经开发了几十年，并且在世界各地已经建立了许多生产设施，但生产成本仍然很高。本文旨在评估当前的生产工艺和生产设施，分析工艺改进的研发策略，并回顾最近的研究进展，以期降低生产成本。通过这些努力，我们希望得出结论，通过进一步的研发，雨生红球藻虾青素的生产成本可能会大幅降低，达到与化学虾青素相当的水平，未来的研究可能需要集中在菌株选择和改良、培养工艺优化、培养方法创新和提取技术革命上。
