Complexo Hospitalario Universitario de Santiago, Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago IDIS, Spain.
Hospital Universitario Vall d'Hebrón, Barcelona, Spain.
J Infect. 2020 Oct;81(4):600-606. doi: 10.1016/j.jinf.2020.07.019. Epub 2020 Jul 22.
To study the prevalence and distribution of HBV genotypes in Spain for the period 2000-2016.
Retrospective study recruiting 2559 patients from 17 hospitals. Distribution of HBV genotypes, as well as sex, age, geographical origin, mode of transmission, HDV-, HIV- and/or HCV-coinfection, and treatment were recorded.
1924 chronically HBV native Spanish patients have been recruited. Median age was 54 years (IQR: 41-62), 69.6% male, 6.3% HIV-coinfected, 3.1% were HCV-coinfected, 1.7% HDV-co/superinfected. Genotype distribution was: 55.9% D, 33.5% A, 5.6% F, 0.8% G, and 1.9% other genotypes (E, B, H and C). HBV genotype A was closely associated with male sex, sexual transmission, and HIV-coinfection. In contrast, HBV genotype D was associated with female sex and vertical transmission. Different patterns of genotype distribution and diversity were found between different geographical regions. In addition, HBV epidemiological patterns are evolving in Spain, mainly because of immigration. Finally, similar overall rates of treatment success across all HBV genotypes were found.
We present here the most recent data on molecular epidemiology of HBV in Spain (GEHEP010 Study). This study confirms that the HBV genotype distribution in Spain varies based on age, sex, origin, HIV-coinfection, geographical regions and epidemiological groups.
研究 2000-2016 年期间西班牙乙型肝炎病毒（HBV）基因型的流行和分布。
回顾性研究，从 17 家医院招募了 2559 名患者。记录 HBV 基因型分布情况，以及性别、年龄、地理来源、传播方式、丁型肝炎病毒（HDV）-、人类免疫缺陷病毒（HIV）-和/或丙型肝炎病毒（HCV）-合并感染情况和治疗情况。
共招募了 1924 名慢性 HBV 原籍西班牙患者。中位年龄为 54 岁（IQR：41-62），69.6%为男性，6.3%合并感染 HIV，3.1%合并感染 HCV，1.7%合并感染 HDV。基因型分布为：55.9%为 D 型，33.5%为 A 型，5.6%为 F 型，0.8%为 G 型，1.9%为其他基因型（E、B、H 和 C）。HBV 基因型 A 与男性、性传播和 HIV 合并感染密切相关。相比之下，HBV 基因型 D 与女性和垂直传播相关。不同地理区域存在不同的基因型分布和多样性模式。此外，HBV 流行病学模式在西班牙正在发生变化，主要是由于移民。最后，我们发现所有 HBV 基因型的总体治疗成功率相似。
我们在此介绍了西班牙 HBV 分子流行病学的最新数据（GEHEP010 研究）。本研究证实，西班牙 HBV 基因型分布因年龄、性别、来源、HIV 合并感染、地理区域和流行病学群体而异。
