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纳武利尤单抗单药治疗后口腔黏膜黑色素瘤患者的远隔效应:病例报告。

Abscopal effect of radiation therapy after nivolumab monotherapy in a patient with oral mucosal melanoma: A case report.

机构信息

Department of Dentistry and Oral Surgery, Akita University Graduate School of Medicine, Akita, Japan; 44-2 Hasunuma, Hiroomote, Akita-shi, Akita, Japan.

Department of Dentistry and Oral Surgery, Akita University Graduate School of Medicine, Akita, Japan; 44-2 Hasunuma, Hiroomote, Akita-shi, Akita, Japan.

出版信息

Oral Oncol. 2020 Sep;108:104919. doi: 10.1016/j.oraloncology.2020.104919. Epub 2020 Jul 23.

DOI:10.1016/j.oraloncology.2020.104919
PMID:32713809
Abstract

The Abscopal effect is a rare phenomenon whereby tumors outside of the irradiated field regress due to systemic antitumor effects of localized radiotherapy. In patients with oral mucosal melanoma, only one instance of the abscopal effect has been described in the English-language literature [1]. Herein, we describe an instance of the abscopal effect following whole-brain radiation therapy after nivolumab monotherapy in a patient with oral mucosal melanoma.

摘要

远隔效应是一种罕见的现象,即由于局部放疗的全身抗肿瘤作用,照射野外的肿瘤消退。在口腔黏膜黑色素瘤患者中,仅有一例远隔效应在英文文献中描述过[1]。在此,我们描述了一例口腔黏膜黑色素瘤患者在接受纳武单抗单药治疗后行全脑放疗出现远隔效应的病例。

相似文献

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Abscopal effect of radiation therapy after nivolumab monotherapy in a patient with oral mucosal melanoma: A case report.纳武利尤单抗单药治疗后口腔黏膜黑色素瘤患者的远隔效应:病例报告。
Oral Oncol. 2020 Sep;108:104919. doi: 10.1016/j.oraloncology.2020.104919. Epub 2020 Jul 23.
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Phase 2 Trial of Nivolumab Combined With Stereotactic Body Radiation Therapy in Patients With Metastatic or Locally Advanced Inoperable Melanoma.纳武利尤单抗联合立体定向放疗治疗转移性或局部晚期不可切除黑色素瘤的 2 期临床试验。
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Int J Clin Oncol. 2020 May;25(5):972-977. doi: 10.1007/s10147-020-01618-9. Epub 2020 Jan 14.

引用本文的文献

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Skeletal Radiol. 2025 May 15. doi: 10.1007/s00256-025-04944-z.
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Abscopal Effect in Metastatic Melanoma: Generating Clinical Insights From Radiation-Induced Immune Response.转移性黑色素瘤中的远隔效应:从辐射诱导的免疫反应中获取临床见解
Cureus. 2024 Nov 1;16(11):e72853. doi: 10.7759/cureus.72853. eCollection 2024 Nov.
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Current Status and Molecular Mechanisms of Resistance to Immunotherapy in Oral Malignant Melanoma.
口腔恶性黑色素瘤的免疫治疗耐药现状及分子机制。
Int J Mol Sci. 2023 Dec 8;24(24):17282. doi: 10.3390/ijms242417282.
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Abscopal Effect on Bone Metastases from Solid Tumors: A Systematic Review and Retrospective Analysis of Challenge within a Challenge.实体瘤骨转移的远隔效应:挑战中的挑战之系统评价与回顾性分析
Biomedicines. 2023 Apr 12;11(4):1157. doi: 10.3390/biomedicines11041157.
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The abscopal effect: systematic review in patients with brain and spine metastases.远隔效应:对脑和脊柱转移瘤患者的系统评价
Neurooncol Adv. 2022 Aug 19;4(1):vdac132. doi: 10.1093/noajnl/vdac132. eCollection 2022 Jan-Dec.
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Analysis Model of Spoken English Evaluation Algorithm Based on Intelligent Algorithm of Internet of Things.基于物联网智能算法的英语口语评估算法分析模型。
Comput Intell Neurosci. 2022 Mar 27;2022:8469945. doi: 10.1155/2022/8469945. eCollection 2022.
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A case of primary malignant melanoma of the esophagogastric junction with abscopal effect after nivolumab administration.一例食管胃交界部原发性恶性黑色素瘤在使用纳武单抗后出现远隔效应。
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