Molecular Biology Department, Prantae Solutions Private Limited, Bhubaneswar 751 024, India.
J Biosci. 2020;45(1). doi: 10.1007/s12038-020-00071-0.
The two biological evidences to endorse the antiviral activity of RNA interference (RNAi) are biogenesis of viral-siRNA (v-siRNA) by the host and encoding of RNAi-suppressor protein by viral genome. It has been recently established that mammals and mammalian cell lines mount antiviral RNAi to defend themselves against the invading viruses. The large part of viral pathogenicity is also due to the RNAi suppressor proteins. In this context it is only natural to ask what kinds of RNAi suppressors are encoded by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the central character of the present pandemic. The following mini review addresses this question.
支持 RNA 干扰 (RNAi) 抗病毒活性的两个生物学证据是宿主生物生成病毒 siRNA (v-siRNA) 和病毒基因组编码 RNAi 抑制蛋白。最近已经确定，哺乳动物和哺乳动物细胞系会产生抗病毒 RNAi 来抵御入侵的病毒。病毒致病性的很大一部分也是由于 RNAi 抑制蛋白。在这种情况下，自然会问一下，引发当前大流行的严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 编码了哪些类型的 RNAi 抑制蛋白。以下简要综述回答了这个问题。
