皮肤红斑狼疮发病机制的最新研究进展。
Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis.
机构信息
Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, United States.
Department of Pathology, University of Massachusetts Medical School, Worcester, MA, United States.
出版信息
Front Immunol. 2020 Jul 2;11:1353. doi: 10.3389/fimmu.2020.01353. eCollection 2020.
Cutaneous Lupus Erythematosus (CLE) is a clinically diverse group of autoimmune skin diseases with shared histological features of interface dermatitis and autoantibodies deposited at the dermal-epidermal junction. Various genetic and environmental triggers of CLE promote infiltration of T cells, B cells, neutrophils, antigen presenting cells, and NK cells into lesional skin. In this mini-review, we will discuss the clinical features of CLE, insights into CLE immunopathogenesis, and novel treatment approaches.
皮肤狼疮（CLE）是一组具有临床多样性的自身免疫性皮肤病，具有界面性皮炎的共同组织学特征和在真皮-表皮交界处沉积的自身抗体。CLE 的各种遗传和环境诱因可促进 T 细胞、B 细胞、中性粒细胞、抗原提呈细胞和 NK 细胞浸润到病变皮肤中。在这篇迷你综述中，我们将讨论 CLE 的临床特征、对 CLE 免疫发病机制的认识，以及新的治疗方法。
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