Britti Elena, Delaspre Fabien, Tamarit Jordi, Ros Joaquim
Department of Basic Medical Sciences, University of Lleida, Faculty of Medicine, IRB Lleida, Lleida, Spain.
Neuronal Signal. 2018 Nov 16;2(4):NS20180061. doi: 10.1042/NS20180061. eCollection 2018 Dec.
Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium buffering, meaning that mitochondrial calcium uptake and release is intimately related to cytosolic calcium concentrations. This review focuses on the proteins contributing to mitochondrial calcium homoeostasis, the roles of the mitochondrial permeability transition pore (MPTP) and mitochondrial calcium-activated proteins, and their relevance in neurodegenerative pathologies. It also covers alterations to calcium homoeostasis in Friedreich ataxia (FA).
钙被细胞用于信号传导和调节ATP生成；它也有助于细胞存活，而当浓度失衡时，会触发细胞死亡途径。线粒体有助于钙缓冲，这意味着线粒体对钙的摄取和释放与胞质钙浓度密切相关。本综述重点关注有助于线粒体钙稳态的蛋白质、线粒体通透性转换孔（MPTP）和线粒体钙激活蛋白的作用，以及它们在神经退行性疾病中的相关性。它还涵盖了弗里德赖希共济失调（FA）中钙稳态的改变。
