Ho Angela Wing Hang, Wong Sze Hung
Department of Orthopaedics and Traumatology, Caritas Medical Centre, Hong Kong.
Osteoporos Sarcopenia. 2020 Jun;6(2):71-74. doi: 10.1016/j.afos.2020.05.004. Epub 2020 Jun 18.
The aim of this study is to investigate the incidence of second hip fractures after a previous hip fracture and subsequent mortality in Chinese men and women.
Data of patients aged 65 years or above with operatively treated hip fracture in the years 2000-2011 in Hong Kong were retrieved from Hospital Authority clinical database. During the follow-up period, second contralateral operatively treated hip fractures were identified. The incidence of a second fracture was determined using survival analysis.
A total of 2399 second hip fractures were identified. The cumulative incidence of a second fracture was 1.24% at 1 year and 4.42% at 5 years with 60% of second fractures occurring within 4 years after the initial fracture. In cox regression model, a higher incidence was observed as age increased (hazard ratio [HR], 1.08; P < 0.001). The cumulative mortality at 1 and 5 years after a second fracture was 16.9% and 54.8%, respectively. The median survival after single fracture was 4.9 years, while after a second fracture it was 3.8 years (P < 0.05). Lower survival was observed after the second fracture (HR, 5.44; P < 0.05), in men (HR, 1.91; P < 0.05) and older patients (HR, 1.061; P < 0.05).
Patients with history of hip fracture are at high risk to develop a second fracture. Initiation of treatment and fragility fracture prevention program after primary hip fracture should be started in order to reduce second fracture incidence and related mortality.
本研究旨在调查中国男性和女性既往髋部骨折后再次发生髋部骨折的发生率及随后的死亡率。
从医院管理局临床数据库中检索2000年至2011年在香港接受手术治疗的65岁及以上髋部骨折患者的数据。在随访期间,确定对侧再次接受手术治疗的髋部骨折情况。使用生存分析确定再次骨折的发生率。
共识别出2399例再次髋部骨折。再次骨折的累积发生率在1年时为1.24%,5年时为4.42%,其中60%的再次骨折发生在初次骨折后的4年内。在Cox回归模型中,随着年龄的增加,再次骨折的发生率更高(风险比[HR],1.08;P<0.001)。再次骨折后1年和5年的累积死亡率分别为16.9%和54.8%。单次骨折后的中位生存期为4.9年,而再次骨折后为3.8年(P<0.05)。再次骨折后(HR,5.44;P<0.05)、男性(HR,1.91;P<0.05)和老年患者(HR,1.061;P<0.05)的生存期较低。
有髋部骨折病史的患者发生再次骨折的风险很高。应在初次髋部骨折后启动治疗和脆性骨折预防计划,以降低再次骨折的发生率及相关死亡率。