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本文引用的文献

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COVID-19-associated nephritis: early warning for disease severity and complications?新型冠状病毒肺炎相关肾炎：疾病严重程度和并发症的早期预警？
Lancet. 2020 May 16;395(10236):e87-e88. doi: 10.1016/S0140-6736(20)31041-2. Epub 2020 May 6.
2
Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease From Other Neurodegenerative Disorders.RO948 F 18 tau 正电子发射断层扫描在阿尔茨海默病与其他神经退行性疾病鉴别诊断中的性能。
JAMA Neurol. 2020 Aug 1;77(8):955-965. doi: 10.1001/jamaneurol.2020.0989.
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Convalescent plasma in Covid-19: Possible mechanisms of action.恢复期血浆治疗 COVID-19：可能的作用机制。
Autoimmun Rev. 2020 Jul;19(7):102554. doi: 10.1016/j.autrev.2020.102554. Epub 2020 May 5.
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COVID-19 and stroke-A global World Stroke Organization perspective.COVID-19 与脑卒中——世界卒中组织的全球视角。
Int J Stroke. 2020 Jun;15(4):361-364. doi: 10.1177/1747493020923472. Epub 2020 Apr 29.
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The Spectrum of Neurologic Disease in the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic Infection: Neurologists Move to the Frontlines.严重急性呼吸综合征冠状病毒2大流行感染中的神经系统疾病谱：神经科医生奔赴前线。
JAMA Neurol. 2020 Jun 1;77(6):679-680. doi: 10.1001/jamaneurol.2020.1065.
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Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.中国武汉住院的 2019 年冠状病毒病患者的神经系统表现。
JAMA Neurol. 2020 Jun 1;77(6):683-690. doi: 10.1001/jamaneurol.2020.1127.
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Association Between Lifetime Affective Symptoms and Premature Mortality.终生情感症状与早逝之间的关联。
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Effectiveness of convalescent plasma therapy in severe COVID-19 patients.恢复期血浆疗法治疗重症 COVID-19 患者的疗效。
Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9490-9496. doi: 10.1073/pnas.2004168117. Epub 2020 Apr 6.
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新型冠状病毒肺炎的神经和免疫并发症：阿尔茨海默病潜在的长期风险因素

Neurologic and Immunologic Complications of COVID-19: Potential Long-Term Risk Factors for Alzheimer's Disease.

作者信息

Lennon Jack C

机构信息

Department of Psychology, Adler University, Chicago, IL, USA.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

出版信息

J Alzheimers Dis Rep. 2020 Jun 16;4(1):217-221. doi: 10.3233/ADR-200190.

DOI:10.3233/ADR-200190
PMID:32715280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7369139/
Abstract

The COVID-19 pandemic has been met with studies on risk factors, characteristics, and clinical course. Among these characteristics are neurologic symptoms, which may provide improved insight into the mechanisms of this novel virus and the brain's susceptibility to infectious diseases. This article aims to discuss 1) findings related to neurologic complications, 2) how they connect to and are bidirectionally impacted by bioimmunology, 3) how this combination of biological mechanisms impact and are impacted by psychosocial stressors, and 4) the importance of considering potential neurodegenerative consequences of COVID-19. Longitudinal studies on neuropathology and cognition are critical to avoiding premature conclusions related to long-term neurologic effects.

摘要

针对新冠疫情开展了诸多关于风险因素、特征及临床病程的研究。这些特征中包括神经系统症状，这或许能让人们更深入地了解这种新型病毒的作用机制以及大脑对传染病的易感性。本文旨在探讨：1）与神经系统并发症相关的研究结果；2）这些并发症如何与生物免疫学相互关联并受到其双向影响；3）这种生物机制的组合如何影响心理社会压力源以及受到心理社会压力源的何种影响；4）考虑新冠病毒潜在神经退行性后果的重要性。关于神经病理学和认知的纵向研究对于避免过早得出与长期神经影响相关的结论至关重要。