Uszycka-Karcz M, Marczak E, Mierzewski P, Zurowska A, Schramm K, Gockowska Z
Pediatric Clinic of Nephrology, Gdańsk, Poland.
Child Nephrol Urol. 1988;9(5):264-8.
During 1972-1986, 142 children with the hemolytic-uremic syndrome were treated. Most of them were infants (73%). The total mortality rate reached 25.4%. Computer analysis revealed the following risk factors of a fatal outcome: severe gastrointestinal symptoms during the prodromal period, coma, convulsions, malignant hypertension, persistence of prodromal symptoms over 7 days, hyperkalemia over 7 mmol/l, acidosis with bicarbonate level less than 15 mmol/l, a delay of over 5 days in starting dialysis, and transport to dialysis unit of over 100 km. The greatest risk of death existed during the first 3 weeks from onset. Among 142 children, 106 survived the acute phase. They were followed up from 2 to 16 years. Nine were lost to follow-up. Twelve children developed chronic renal failure.
1972年至1986年间，对142例溶血尿毒综合征患儿进行了治疗。其中大多数为婴儿（73%）。总死亡率达25.4%。计算机分析揭示了以下导致致命结局的危险因素：前驱期出现严重胃肠道症状、昏迷、惊厥、恶性高血压、前驱症状持续超过7天、血钾超过7 mmol/L、碳酸氢盐水平低于15 mmol/L的酸中毒、开始透析延迟超过5天以及转运至透析单位的距离超过100公里。发病后的前3周内死亡风险最高。142例患儿中，106例度过急性期存活下来。对他们进行了2至16年的随访。9例失访。12例患儿发展为慢性肾衰竭。
