Dalvi R R, Trivedi S J
School of Veterinary Medicine, Tuskegee University, AL 36088.
Drug Metabol Drug Interact. 1988;6(3-4):285-93. doi: 10.1515/dmdi.1988.6.3-4.285.
No significant increases in serum SDH, ALT and AST activities were observed in goats and rats receiving oral sulfadimethoxine at 5 times the therapeutic dose. The quail showed significantly higher activities of SDH and ALT when compared to control values. Moderate increases in liver microsomal cytochrome P-450 and aniline hydroxylase activity were observed in goats and quail but no appreciable change in benzphetamine N-demethylase activity was detected in any species. These results suggest a lack of hepatic toxicity of sulfadimethoxine to these species under the reported experimental conditions.
