Laboratory of Enzymology and Recombinant DNA Technology, Department of Microbiology, Maharshi Dayanand University, Rohtak, 124001, Haryana, India.
Laboratory of Enzymology and Recombinant DNA Technology, Department of Microbiology, Maharshi Dayanand University, Rohtak, 124001, Haryana, India.
Virus Res. 2020 Sep;286:198103. doi: 10.1016/j.virusres.2020.198103. Epub 2020 Jul 24.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a major pandemic called coronavirus disease 2019 (COVID-19) that has created unprecedented global health emergencies, and emerged as a serious threat due to its strong ability for human-to-human transmission. The reports indicate the ability of SARS-CoV-2 to affect almost any organ due to the presence of a receptor known as angiotensin converting enzyme 2 (ACE2) across the body. ACE2 receptor is majorly expressed in the brush border of gut enterocytes along with the ciliated cells and alveolar epithelial type II cells in the lungs. The amino acid transport function of ACE2 has been linked to gut microbial ecology in gastrointestinal (GI) tract, thereby suggesting that COVID-19 may, to some level, be linked to the enteric microbiota. The significant number of COVID-19 patients shows extra-pulmonary symptoms in the GI tract. Many subsequent studies revealed viral RNA of SARS-CoV-2 in fecal samples of COVID-19 patients. This presents a new challenge in the diagnosis and control of COVID-19 infection with a caution for proper sanitation and hygiene. Here, we aim to discuss the immunological co-ordination between gut and lungs that facilitates SARS-CoV-2 to infect and multiply in the inflammatory bowel disease (IBD) and non-IBD patients.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）已经演变成一种称为 2019 年冠状病毒病（COVID-19）的主要大流行疾病，它造成了前所未有的全球卫生紧急情况，由于其具有很强的人际传播能力，已成为严重威胁。有报道表明，由于 SARS-CoV-2 能够在全身表达一种称为血管紧张素转换酶 2（ACE2）的受体，因此几乎可以影响任何器官。ACE2 受体主要在肠道肠上皮细胞的刷状缘以及肺部的纤毛细胞和肺泡上皮细胞 II 型中表达。ACE2 的氨基酸转运功能与胃肠道（GI）中的肠道微生物生态学有关，这表明 COVID-19 可能在一定程度上与肠微生物群有关。大量 COVID-19 患者在胃肠道中表现出肺部以外的症状。许多后续研究揭示了 COVID-19 患者粪便样本中的 SARS-CoV-2 病毒 RNA。这给 COVID-19 感染的诊断和控制带来了新的挑战，需要注意适当的卫生和卫生。在这里，我们旨在讨论肠道和肺部之间的免疫协调作用，这使得 SARS-CoV-2 能够在炎症性肠病（IBD）和非 IBD 患者中感染和繁殖。
