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纤维肌痛症女性的血浆蛋白质组谱与疼痛强度、敏感性和心理困扰之间存在显著相关性。

Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia.

机构信息

Pain and Rehabilitation Center, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.

Department of Dental Medicine, Karolinska Institutet and Scandinavian Center for Orofacial Neurosciences (SCON), 141 04, Huddinge, Sweden.

出版信息

Sci Rep. 2020 Jul 27;10(1):12508. doi: 10.1038/s41598-020-69422-z.

DOI:10.1038/s41598-020-69422-z
PMID:32719459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7385654/
Abstract

Fibromyalgia (FM) is a complex pain condition where the pathophysiological and molecular mechanisms are not fully elucidated. The primary aim of this study was to investigate the plasma proteome profile in women with FM compared to controls. The secondary aim was to investigate if plasma protein patterns correlate with the clinical variables pain intensity, sensitivity, and psychological distress. Clinical variables/background data were retrieved through questionnaires. Pressure pain thresholds (PPT) were assessed using an algometer. The plasma proteome profile of FM (n = 30) and controls (n = 32) was analyzed using two-dimensional gel electrophoresis and mass spectrometry. Quantified proteins were analyzed regarding group differences, and correlations to clinical parameters in FM, using multivariate statistics. Clear significant differences between FM and controls were found in proteins involved in inflammatory, metabolic, and immunity processes. Pain intensity, PPT, and psychological distress in FM had associations with specific plasma proteins involved in blood coagulation, metabolic, inflammation and immunity processes. This study further confirms that systemic differences in protein expression exist in women with FM compared to controls and that altered levels of specific plasma proteins are associated with different clinical parameters.

摘要

纤维肌痛（FM）是一种复杂的疼痛病症，其病理生理和分子机制尚未完全阐明。本研究的主要目的是比较女性纤维肌痛患者和对照组的血浆蛋白质组谱。次要目的是研究血浆蛋白模式是否与疼痛强度、敏感性和心理困扰等临床变量相关。通过问卷调查获取临床变量/背景数据。使用压力测定计评估压痛阈值（PPT）。使用二维凝胶电泳和质谱分析纤维肌痛（n=30）和对照组（n=32）的血浆蛋白质组谱。使用多元统计分析，对组间差异和纤维肌痛临床参数进行定量蛋白分析。FM 组与对照组之间在涉及炎症、代谢和免疫过程的蛋白质方面存在明显差异。FM 中的疼痛强度、PPT 和心理困扰与涉及血液凝固、代谢、炎症和免疫过程的特定血浆蛋白有关。本研究进一步证实，与对照组相比，女性纤维肌痛患者的蛋白质表达存在系统性差异，并且特定血浆蛋白水平的改变与不同的临床参数相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/4df306b9c7f2/41598_2020_69422_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/a41b63485a5a/41598_2020_69422_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/8189ad22d6d2/41598_2020_69422_Fig5_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/d24a774bfc48/41598_2020_69422_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/d069632ff853/41598_2020_69422_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/4df306b9c7f2/41598_2020_69422_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/a41b63485a5a/41598_2020_69422_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/986645aedc4f/41598_2020_69422_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/57dde9748e37/41598_2020_69422_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/fb95053fc28b/41598_2020_69422_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/8189ad22d6d2/41598_2020_69422_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/d421e4165925/41598_2020_69422_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/d24a774bfc48/41598_2020_69422_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/d069632ff853/41598_2020_69422_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a918/7385654/4df306b9c7f2/41598_2020_69422_Fig9_HTML.jpg

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