Gallagher Kristalyn K, Lopez Marcos, Iles Kathleen, Kugar Meredith
The University of North Carolina at Chapel Hill, Campus Box 7213, 1150 POB, 170, Dr. Chapel Hill, Manning, NC, 27599-7213, USA.
Curr Oncol Rep. 2020 Jul 28;22(10):97. doi: 10.1007/s11912-020-00961-4.
For patients who have or may develop lymphedema due to oncologic resection, surgical options are available to prevent and treat this chronic disease. Here, we review the current pathophysiology, classification systems, surgical preventive techniques, and treatment options for lymphedema reduction.
Preventive surgical techniques, including de-escalation of axillary surgery, sentinel lymph node biopsy (SLNB), axillary reverse mapping (ARM), and lymphedema microsurgical preventive healing approach (LYMPHA), have been shown to reduce the incidence of lymphedema. Water displacement remains the gold standard for measuring limb volume and classification of lymphedema; however, lymphoscintigraphy and ICG lymphography are two novel imaging techniques that are now utilized to characterize lymphedema and guide management. Complete decongestive therapy (CDT) remains the mainstay of treatment. Vascularized lymph node transfer (VLNT) and lymphovenous bypass have shown promising results, particularly in advanced lymphedema stages. Combination therapy, incorporating both surgical and non-surgical approaches to lymphedema, yields best patient outcomes. Lymphedema is a chronic disease wherein management requires a combination of surgical and conservative treatments. Standardization in lymphedema staging, key outcome indicators, and quantitative data will be critical to establish the absolute best practices in lymphedema diagnosis and treatment.
对于因肿瘤切除而已经发生或可能发生淋巴水肿的患者,有多种手术选择可用于预防和治疗这种慢性疾病。在此,我们综述淋巴水肿的当前病理生理学、分类系统、手术预防技术以及减轻淋巴水肿的治疗选择。
预防性手术技术,包括腋窝手术降级、前哨淋巴结活检(SLNB)、腋窝反向映射(ARM)和淋巴水肿显微外科预防性愈合方法(LYMPHA),已被证明可降低淋巴水肿的发生率。水置换仍然是测量肢体体积和淋巴水肿分类的金标准;然而,淋巴闪烁造影和吲哚菁绿淋巴造影是两种新型成像技术,现在用于表征淋巴水肿并指导治疗。完全减压疗法(CDT)仍然是主要的治疗方法。带血管蒂淋巴结转移(VLNT)和淋巴静脉旁路已显示出有前景的结果,特别是在淋巴水肿晚期。结合手术和非手术方法治疗淋巴水肿的联合疗法可产生最佳的患者预后。淋巴水肿是一种慢性疾病,其管理需要手术和保守治疗相结合。淋巴水肿分期、关键结局指标和定量数据的标准化对于确立淋巴水肿诊断和治疗的绝对最佳实践至关重要。