Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Ophthalmology, University of Florida, Gainesville, FL, USA.
Int Ophthalmol. 2020 Dec;40(12):3295-3302. doi: 10.1007/s10792-020-01516-z. Epub 2020 Jul 27.
To evaluate the changes on optical coherence tomography angiography (OCTA) in macula-off rhegmatogenous retinal detachments (RRD) treated with pars plana vitrectomy (PPV) and silicone oil (SO) 5000-cSt tamponade.
Forty-five eyes with macula-off RRD treated with PPV and SO tamponade were enrolled with the fellow eye being used as a control. OCT-A was obtained using the RTVue XR 100 Avanti (Optovue, Inc., Fremont, CA, USA) at the 1-week, 1-month, and 3-month postoperative visit. Retinal vascular density, choroidal flow area, retinal thickness, and foveal avascular zone area were evaluated at each follow-up visit. Changes in these parameters in the postoperative eye were tracked at each follow-up visit as were the relative differences between the postoperative eye and the contralateral eye.
Vascular density of parafoveal superficial capillary plexus and total retina demonstrated significant decrease in the postoperative silicone-filled eye when compared to the fellow eye (P < 0.0001). Although there was some improvement in these values at subsequent follow-ups, they remained less than the fellow eye. Foveal (P = 0.002) and parafoveal (P < 0.0001) thickness were less than the fellow eye. Choroidal flow area did not show a significant change in operated eye compared with the fellow eye.
Eyes with macula-off RRD repaired with PPV and SO, at 3-month follow-up, demonstrated less retinal vascular density at parafoveal area as well as lower retinal thickness at fovea when compared to the healthy fellow eyes.
评估经玻璃体切除术（PPV）联合硅油（SO）5000-cSt 填充治疗黄斑脱离性孔源性视网膜脱离（RRD）后光学相干断层扫描血管造影（OCTA）的变化。
共纳入 45 例接受 PPV 和 SO 填充治疗黄斑脱离性 RRD 的患眼，并以对侧眼作为对照。在术后 1 周、1 个月和 3 个月，使用 RTVue XR 100 Avanti（Optovue，Inc.，加利福尼亚州弗里蒙特）进行 OCT-A 检查。在每次随访时评估视网膜血管密度、脉络膜血流面积、视网膜厚度和中心凹无血管区面积。在每次随访时跟踪术后眼的这些参数变化，并比较术后眼与对侧眼的相对差异。
与对侧眼相比，术后硅油填充眼的旁中心浅层毛细血管丛和全视网膜血管密度显著下降（P<0.0001）。尽管在随后的随访中这些值有所改善，但仍低于对侧眼。中心凹（P=0.002）和旁中心（P<0.0001）厚度均小于对侧眼。与对侧眼相比，手术眼的脉络膜血流面积没有明显变化。
接受 PPV 和 SO 修复的黄斑脱离性 RRD 患者，在术后 3 个月时，与健康对侧眼相比，旁中心区视网膜血管密度较低，中心凹视网膜厚度较低。
