Yeni Yüzyıl University, Gaziosmanpaşa Hospital, Maltepe Mahallesi, Yılanlı Ayazma Caddesi, No: 26 Cevizlibağ, 34010, Zeytinburnu, Istanbul, Turkey.
Beyoğlu Eye Trainning and Research Hospital, Bereketzade, Bereketzade Cami Sk. No:2, 34421, Beyoğlu, Istanbul, Turkey.
Int Ophthalmol. 2022 Jun;42(6):1963-1973. doi: 10.1007/s10792-021-02196-z. Epub 2022 Jan 8.
To investigate the longitudinal retinal vascular and structural alterations by using OCTA following successful repair of retinal detachment (RD) by using silicone oil (SO) endotamponade.
A prospective cohort study was performed on 24 eyes of 24 subjects; 17 of them with macula-off and seven with macula-on RD. At least four OCTA scans were generated for each study eye; two before and two after SO removal (SOR). At each session, retinal thickness (RT), vascular density (VD) in the superficial (SCP) and deep capillary plexuses (DCP) and foveal avascular zone(FAZ) size were measured within the fovea, parafovea and whole macular image. The changes in repeated measures of the same parameters especially before and after SOR were performed and compared within macula-on and macula-off groups and between fellow eyes.
"In the macula-off eyes, RT measurements within the whole macula, fovea and parafovea reduced as compared with their fellow eyes(p < 0.0001, p = 0.001 and p < 0.0001, respectively) and did not improve after SOR. Additionally, all of the whole macular, foveal, and parafoveal VD measurements at SCP and foveal VD at DCP were less than their fellow eyes after SOR (p = 0.026, p = 0.023 p = 0.026, and p = 0.002, respectively). In macula-on eyes, RT measurements decreased within the parafovea and whole macular area before SOR (p = 0.018 and p = 0.011, respectively) but improved after SOR. Also, VD measurements did not change during follow-up and were not statistically different than their fellow eyes (p > 0.05). FAZ enlargement was found in eyes with macular-off RD after SOR, whereas it was not observed with macular-on RD (p = 0.038and p = 0.237, respectively).
Treatment of macula-off RD with SO tamponade has been associated with vascular retinal abnormalities which did not improve following SOR. On the contrary, successful treatment of RD with SO tamponade in macula-on eyes VD measurements of SCP and DCP were not statistically different than their fellow eyes.
研究硅油（SO）眼内填充成功修复视网膜脱离（RD）后视网膜血管和结构的纵向变化。
对 24 名患者的 24 只眼进行前瞻性队列研究；其中 17 只眼为黄斑脱离，7 只眼为黄斑未脱离 RD。每只研究眼至少生成 4 次 OCTA 扫描；SO 取出前 2 次，SO 取出后 2 次。在每次检查中，在黄斑中心凹、旁中心凹和整个黄斑图像内测量视网膜厚度（RT）、浅层毛细血管丛（SCP）和深层毛细血管丛（DCP）的血管密度（VD）和黄斑中心凹无血管区（FAZ）大小。对 SOR 前后同一参数的重复测量变化进行了比较，并在黄斑脱离眼和黄斑未脱离眼之间以及对侧眼之间进行了比较。
在黄斑脱离眼，与对侧眼相比，整个黄斑、黄斑中心凹和旁中心凹的 RT 测量值均降低（p<0.0001，p=0.001 和 p<0.0001），且 SOR 后未见改善。此外，SCP 全黄斑、黄斑中心凹和旁中心凹以及 DCP 黄斑中心凹 VD 测量值均低于对侧眼（p=0.026，p=0.023，p=0.026 和 p=0.002）。在黄斑未脱离眼，SOR 前旁中心凹和全黄斑区 RT 测量值降低（p=0.018 和 p=0.011），但 SOR 后改善。此外，随访期间 VD 测量值无变化，与对侧眼无统计学差异（p>0.05）。黄斑脱离 RD 眼 SOR 后发现 FAZ 扩大，而黄斑未脱离 RD 眼未见 FAZ 扩大（p=0.038 和 p=0.237）。
SO 眼内填充治疗黄斑脱离 RD 可引起视网膜血管异常，且 SOR 后未见改善。相反，SO 眼内填充成功治疗黄斑未脱离 RD 后，SCP 和 DCP 的 VD 测量值与对侧眼无统计学差异。
