Yang Fujun, Dong Zhengwei, Shen Yingran, Shi Jinghan, Wu Yulin, Zhao Zhipeng, Jiang Gening, Song Xiao
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China.
Department of Pathology, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China.
Lung Cancer. 2020 Sep;147:187-192. doi: 10.1016/j.lungcan.2020.07.021. Epub 2020 Jul 21.
The predictive value of prognosis based on the histopathological subtype is a critical criterion in the new classification of lung adenocarcinoma published in 2011 by the International Association for the Study of Lung Cancer (IASLC), the American Thoracic Society (ATS), and the European Respiratory Society (ERS) (IASLC/ATS/ERS). In this new classification, the differences of histopathology and prognosis are two considerable parameters to classify the subtypes of lung adenocarcinoma. Cribriform growth pattern is regarded as a variant of acinar growth pattern in lung adenocarcinoma, however, more and more studies pointed out that cribriform growth pattern is associated with more aggressive histopathological structures, higher proportion of recurrence rates, and shorter postoperative survival than acinar growth pattern. These features are similar to solid or micropapillary predominant adenocarcinoma. In this review, we summarized the clinicopathological features, prognosis, and genetic variations of cribriform growth pattern of lung adenocarcinoma, and provided a novel insight into the diagnosis and treatment of cribriform lung adenocarcinoma.
基于组织病理学亚型的预后预测价值是国际肺癌研究协会（IASLC）、美国胸科学会（ATS）和欧洲呼吸学会（ERS）于2011年发布的肺腺癌新分类中的一个关键标准（IASLC/ATS/ERS）。在这个新分类中，组织病理学和预后的差异是对肺腺癌亚型进行分类的两个重要参数。筛状生长模式在肺腺癌中被视为腺泡生长模式的一种变体，然而，越来越多的研究指出，与腺泡生长模式相比，筛状生长模式与更具侵袭性的组织病理学结构、更高的复发率以及更短的术后生存期相关。这些特征与实体或微乳头为主型腺癌相似。在本综述中，我们总结了肺腺癌筛状生长模式的临床病理特征、预后及基因变异情况，并为筛状型肺腺癌的诊断和治疗提供了新的见解。
