Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China.
College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China.
Int J Mol Sci. 2020 Jul 24;21(15):5246. doi: 10.3390/ijms21155246.
The hematopoietic system is becoming increasingly attractive for its simple blood cell lineage and its developmental and functional parallels with the vertebrate system. As the dedicated organ for larval hematopoiesis, the lymph gland harbors both multipotent stem-like progenitor cells and differentiated blood cells. The balance between progenitor maintenance and differentiation in the lymph gland must be precisely and tightly controlled. Multiple developmental signaling pathways, such as Notch, Hedgehog, and Wnt/Wingless, have been demonstrated to regulate the hematopoietic processes in the lymph gland. Focusing on blood cell maintenance and differentiation, this article summarizes the functions of several classic developmental signaling pathways for lymph gland growth and patterning, highlighting the important roles of developmental signaling during lymph gland development as well as larval hematopoiesis.
造血系统因其简单的血细胞谱系及其与脊椎动物系统的发育和功能相似性而越来越受到关注。作为幼虫造血的专用器官，淋巴腺既包含多能干细胞样祖细胞，也包含分化的血细胞。淋巴腺中祖细胞的维持和分化之间的平衡必须得到精确和严格的控制。已经证明，多个发育信号通路，如 Notch、Hedgehog 和 Wnt/Wingless，调节淋巴腺中的造血过程。本文聚焦于血细胞的维持和分化，总结了几个经典的发育信号通路在淋巴腺生长和模式形成中的功能，强调了发育信号在淋巴腺发育以及幼虫造血过程中的重要作用。
