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Dpp 依赖性造血干细胞在 的幼虫淋巴腺中产生 Hh 依赖性血液祖细胞。

Dpp dependent Hematopoietic stem cells give rise to Hh dependent blood progenitors in larval lymph gland of .

机构信息

Developmental Genetics Laboratory, Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, Mohali, India.

Molecular Cell and Developmental Biology Laboratory, Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, Mohali, India.

出版信息

Elife. 2016 Oct 26;5:e18295. doi: 10.7554/eLife.18295.

DOI:10.7554/eLife.18295
PMID:27782877
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5120881/
Abstract

hematopoiesis bears striking resemblance with that of vertebrates, both in the context of distinct phases and the signaling molecules. Even though, there has been no evidence of Hematopoietic stem cells (HSCs) in , the larval lymph gland with its Hedgehog dependent progenitors served as an invertebrate model of progenitor biology. Employing lineage-tracing analyses, we have now identified expressing HSCs in the first instar larval lymph gland. Our studies clearly establish the hierarchical relationship between expressing HSCs and the previously described expressing progenitors. These HSCs require Decapentapelagic (Dpp) signal from the hematopoietic niche for their maintenance in an identical manner to vertebrate aorta-gonadal-mesonephros (AGM) HSCs. Thus, this study not only extends the conservation across these divergent taxa, but also provides a new model that can be exploited to gain better insight into the AGM related Hematopoietic stem cells (HSCs).

摘要

造血过程与脊椎动物的造血过程惊人地相似，无论是在不同阶段还是信号分子方面。尽管如此，在 中并没有造血干细胞 (HSCs) 的证据，但幼虫的淋巴腺及其依赖 Hedgehog 的祖细胞为祖细胞生物学提供了一个无脊椎动物模型。通过谱系追踪分析，我们现在已经在第一龄幼虫的淋巴腺中鉴定出表达 HSCs 的 。我们的研究清楚地确立了表达 HSCs 和之前描述的表达祖细胞之间的层次关系。这些 HSCs 需要来自造血生态位的 Decapentaplegic (Dpp) 信号来维持，这与脊椎动物主动脉性腺中肾 (AGM) HSCs 相同。因此，这项研究不仅扩展了这些不同分类群之间的保守性，而且还提供了一个新的模型，可以用来更好地了解与 AGM 相关的造血干细胞 (HSCs)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/541ac06b348b/elife-18295-resp-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/431ec063c2d2/elife-18295-fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/af4392b69f47/elife-18295-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/541ac06b348b/elife-18295-resp-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/431ec063c2d2/elife-18295-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/085a531f289c/elife-18295-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/5d31377ff951/elife-18295-fig1-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/f98ee614325a/elife-18295-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/dd805bc2e94a/elife-18295-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/9317ae7ce050/elife-18295-fig2-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/94d380703da4/elife-18295-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/e8727b5b1d43/elife-18295-fig3-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/91fc17240752/elife-18295-fig3-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/56a7290255d2/elife-18295-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/7194d312f013/elife-18295-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/005bad93cdd0/elife-18295-fig5-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/ddd7bc9a0796/elife-18295-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/4abdb5cb2900/elife-18295-fig6-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/c5c22bf4d90c/elife-18295-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/5c51b204448b/elife-18295-fig7-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/af4392b69f47/elife-18295-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/5120881/541ac06b348b/elife-18295-resp-fig1.jpg

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