Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095
Molecular Biology Institute, University of California, Los Angeles, California 90095.
Genetics. 2019 Feb;211(2):367-417. doi: 10.1534/genetics.118.300223.
In this FlyBook chapter, we present a survey of the current literature on the development of the hematopoietic system in The blood system consists entirely of cells that function in innate immunity, tissue integrity, wound healing, and various forms of stress response, and are therefore functionally similar to myeloid cells in mammals. The primary cell types are specialized for phagocytic, melanization, and encapsulation functions. As in mammalian systems, multiple sites of hematopoiesis are evident in and the mechanisms involved in this process employ many of the same molecular strategies that exemplify blood development in humans. blood progenitors respond to internal and external stress by coopting developmental pathways that involve both local and systemic signals. An important goal of these studies is to develop the tools and mechanisms critical to further our understanding of human hematopoiesis during homeostasis and dysfunction.
在这本 FlyBook 章节中，我们对造血系统发育的当前文献进行了调查。血液系统完全由在先天免疫、组织完整性、伤口愈合和各种形式的应激反应中发挥作用的细胞组成，因此在功能上与哺乳动物中的髓系细胞相似。主要细胞类型专门用于吞噬、黑色素形成和包裹功能。与哺乳动物系统一样，在 中可以明显看到多个造血部位，并且涉及这个过程的机制采用了许多相同的分子策略，这些策略是人类血液发育的典范。 血液祖细胞通过利用涉及局部和全身信号的发育途径来应对内部和外部压力。这些 研究的一个重要目标是开发工具和机制，这对于进一步理解人类在稳态和功能障碍期间的造血作用至关重要。
