Rog Joanna, Błażewicz Anna, Juchnowicz Dariusz, Ludwiczuk Agnieszka, Stelmach Ewa, Kozioł Małgorzata, Karakula Michal, Niziński Przemysław, Karakula-Juchnowicz Hanna
1st Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, 20-439 Lublin, Poland.
Chair of Chemistry, Department of Analytical Chemistry, Medical University of Lublin, 20-093 Lublin, Poland.
Biomedicines. 2020 Jul 24;8(8):243. doi: 10.3390/biomedicines8080243.
A growing body of evidence confirms abnormal fatty acid (FAs) metabolism in the pathophysiology of schizophrenia. Omega-3 polyunsaturated fatty acids (PUFAs) are endogenous ligands of the G protein-coupled receptors, which have anti-inflammatory properties and are a therapeutic target in many diseases. No clinical studies are concerned with the role of the GPR120 signaling pathway in schizophrenia. The aim of the study was to determine the differences in PUFA nutritional status and metabolism between patients with schizophrenia (SZ group) and healthy individuals (HC group). The study included 80 participants (40 in the SZ group, 40 in the HC group). There were no differences in serum GPR120 and PUFA concentrations and PUFA intake between the examined groups. In the HC group, there was a relationship between FAs in serum and GPR120 concentration ( < 0.05): α-linolenic acid (ALA) ( = -0.46), docosahexaenoic acid (DHA) ( = -0.54), omega-3 PUFAs ( = -0.41), arachidonic acid (AA) ( = -0.44). In the SZ group, FA serum concentration was not related to GPR120 ( > 0.05). In the HC group, ALA and DHA serum concentrations were independently associated with GPR120 ( < 0.05) in the model adjusted for eicosapentaenoic acid (EPA) and accounted for 38.59% of GPR120 variability ( < 0.05). Our results indicate different metabolisms of FAs in schizophrenia. It is possible that the diminished anti-inflammatory response could be a component connecting GPR120 insensitivity with schizophrenia.
越来越多的证据证实，脂肪酸（FAs）代谢异常在精神分裂症的病理生理学中存在。ω-3多不饱和脂肪酸（PUFAs）是G蛋白偶联受体的内源性配体，具有抗炎特性，是许多疾病的治疗靶点。尚无临床研究关注GPR120信号通路在精神分裂症中的作用。本研究的目的是确定精神分裂症患者（SZ组）和健康个体（HC组）之间PUFA营养状况和代谢的差异。该研究纳入了80名参与者（SZ组40名，HC组40名）。在被检查的组之间，血清GPR120和PUFA浓度以及PUFA摄入量没有差异。在HC组中，血清中的脂肪酸与GPR120浓度之间存在关联（<0.05）：α-亚麻酸（ALA）（=-0.46）、二十二碳六烯酸（DHA）（=-0.54）、ω-3多不饱和脂肪酸（=-0.41）、花生四烯酸（AA）（=-0.44）。在SZ组中，脂肪酸血清浓度与GPR120无相关性（>0.05）。在HC组中，在针对二十碳五烯酸（EPA）进行校正的模型中，ALA和DHA血清浓度与GPR120独立相关（<0.05），并占GPR120变异性的38.59%（<0.05）。我们的结果表明精神分裂症中脂肪酸的代谢不同。抗炎反应减弱可能是将GPR120不敏感与精神分裂症联系起来的一个因素。
