Pridmore Saxby, Turnier-Shea Yvonne, Erger Sheila, May Tamara
School of Medicine, University of Tasmania, Australia.
TMS Department, Saint Helen's Hospital, Australia.
Australas Psychiatry. 2021 Apr;29(2):222-225. doi: 10.1177/1039856220943033. Epub 2020 Jul 28.
To determine the impact of clustered maintenance transcranial magnetic stimulation (TMS) on irritability occurring in treatment-resistant major depressive disorder (MDD).
A naturalistic study of 106 courses that includes pre- and posttreatment assessments of subjective and objective depression and a subjective measure of irritability developed for this study.
Forty-six participants (35 females), mean age 43.2 years (14.3), completed 106 courses. There was a significant reduction in irritability and depression scores ( < .001). The change in irritability scores was significantly correlated with the change in depression scores, = .40, < .001.
TMS has the capacity to reduce the irritability co-occurring with treatment-resistant MDD, known to be responsive to TMS. This increases the possibility of using TMS in the treatment of irritability co-occurring with other disorders or standing alone (should irritability be categorized as a stand-alone disorder).
确定集群式维持经颅磁刺激（TMS）对难治性重度抑郁症（MDD）中出现的易怒情绪的影响。
一项针对106个疗程的自然主义研究，包括治疗前后对主观和客观抑郁的评估，以及为本研究开发的易怒情绪主观测量方法。
46名参与者（35名女性），平均年龄43.2岁（14.3），完成了106个疗程。易怒情绪和抑郁评分显著降低（<.001）。易怒情绪评分的变化与抑郁评分的变化显著相关，r = .40，p < .001。
TMS有能力降低与难治性MDD同时出现的易怒情绪，已知这种易怒情绪对TMS有反应。这增加了将TMS用于治疗与其他疾病同时出现或单独出现的易怒情绪的可能性（前提是易怒情绪应被归类为一种独立疾病）。
