经颅磁刺激（TMS）治疗重度抑郁症——作用机制！
Transcranial Magnetic Stimulation (TMS) for Major Depressive Disorder-Modus Operandi!
机构信息
Pridmore, Discipline of Psychiatry, University of Tasmania, Hobart, Tasmania, Australia.
Turnier-Shea, Hobart TMS, Bellerive Health Hub, Bellerive, Tasmania, Australia.
出版信息
Psychopharmacol Bull. 2023 Aug 11;53(3):55-60.
BACKGROUND
Transcranial magnetic stimulation (TMS) is effective in the management of treatment resistant major depressive disorder (MDD) and has recently become widely available. Our aim was to explore the literature for evidence of the mechanism of action.
METHOD
We examined our own accumulating TMS library, the reference lists of all available papers and used a search engine to collect information. We collated and examined this information under relevant heading.
RESULTS
TMS produces a large number of physiological changes including site of stimulation neurochemical, brain wave and blood flow effects, and distant structure effects including neurotransmitter effects and volume increase. TMS also corrects generalized and local functional connectivity (FC) abnormalities which are a feature of MDD.
CONCLUSION
TMS produces a range of physiological changes. It is unclear which of these underpin its antidepressant. It is likely more than one work synergistically to this end-almost certainly the capacity to correct MDD induced FC abnormalities makes a strong antidepressant contribution.
背景
经颅磁刺激（TMS）在治疗难治性重度抑郁症（MDD）方面有效，且最近已广泛应用。我们旨在探究相关文献以寻找其作用机制的证据。
方法
我们检查了我们自己积累的 TMS 资料库、所有现有论文的参考文献列表，并使用搜索引擎收集信息。我们根据相关标题整理并检查了这些信息。
结果
TMS 产生了大量的生理变化，包括刺激部位的神经化学、脑电波和血流效应，以及远距离结构效应，包括神经递质效应和体积增加。TMS 还纠正了 MDD 的广泛性和局部功能连接（FC）异常。
结论
TMS 产生了一系列的生理变化。目前尚不清楚这些变化中的哪一种是其抗抑郁作用的基础。很可能不止一种变化协同作用达到这一目的——纠正 MDD 诱导的 FC 异常的能力很可能做出了重要的抗抑郁贡献。
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